Literature DB >> 28868581

In human brain ornithine transcarbamylase (OTC) immunoreactivity is strongly expressed in a small number of nitrergic neurons.

Hans-Gert Bernstein1, Hendrik Dobrowolny2, Gerburg Keilhoff3, Johann Steiner2.   

Abstract

There is recent evidence for ornithine transcarbamylase (OTC) expression in adult human brain. We decided to immunocytochemically map OTC throughout brain, and to further characterize OTC-immunopositive neurons. By using double immunolabeling technique for OTC and neuronal nitric oxide synthase (nNOS) OTC protein expression was revealed in a small subset of nitrergic (nNOS) neurons. Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons.

Entities:  

Keywords:  Human brain; Immunocytochemistry; Neuronal nitric oxide synthase; Ornithine transcarbamylase

Mesh：

Substances：

Year:  2017        PMID： 28868581     DOI： 10.1007/s11011-017-0105-2

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  23 in total

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Journal:  Hum Brain Mapp       Date:  2011-11-23       Impact factor: 5.038

4.  Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression.

Authors:  Iris Bertram; Hans-Gert Bernstein; Uwe Lendeckel; Alicja Bukowska; Henrik Dobrowolny; Gerburg Keilhoff; Dimitrios Kanakis; Christian Mawrin; Hendrik Bielau; Peter Falkai; Bernhard Bogerts
Journal:  Ann N Y Acad Sci       Date:  2007-01       Impact factor: 5.691

5.  Citrulline immunohistochemistry may not necessarily identify nitric oxide synthase activity: the pitfall of peptidylarginine deiminase.

Authors:  Gerburg Keilhoff; Gerald Wolf
Journal:  Nitric Oxide       Date:  2003-02       Impact factor: 4.427

6.  Reduced citrulline availability by OTC deficiency in mice is related to reduced nitric oxide production.

Authors:  Yvette C Luiking; Marcella M Hallemeesch; Marcel C van de Poll; Cornelis H C Dejong; Wouter J de Jonge; Wouter H Lamers; Nicolaas E P Deutz
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-08-12       Impact factor: 4.310

7.  Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease.

Authors:  F Bensemain; D Hot; S Ferreira; J Dumont; S Bombois; C-A Maurage; L Huot; X Hermant; E Levillain; C Hubans; F Hansmannel; J Chapuis; J-J Hauw; S Schraen; Y Lemoine; L Buée; C Berr; D Mann; F Pasquier; P Amouyel; J-C Lambert
Journal:  Mol Psychiatry       Date:  2007-09-25       Impact factor: 15.992

8.  Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion.

Authors:  Julie Dumont; Djabaria Meroufel; Christophe Bauters; Franck Hansmannel; Faïza Bensemain; Dominique Cottel; Martial Hamon; Jean-Charles Lambert; Pierre Ducimetière; Philippe Amouyel; Mahmoud Zureik; Thierry Brousseau
Journal:  Am J Hypertens       Date:  2009-07-02       Impact factor: 2.689

Review 9.  Arginine Metabolism Revisited.

Authors:  Sidney M Morris
Journal:  J Nutr       Date:  2016-11-09       Impact factor: 4.798

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Authors:  Michael J Hawrylycz; Ed S Lein; Angela L Guillozet-Bongaarts; Elaine H Shen; Lydia Ng; Jeremy A Miller; Louie N van de Lagemaat; Kimberly A Smith; Amanda Ebbert; Zackery L Riley; Chris Abajian; Christian F Beckmann; Amy Bernard; Darren Bertagnolli; Andrew F Boe; Preston M Cartagena; M Mallar Chakravarty; Mike Chapin; Jimmy Chong; Rachel A Dalley; Barry David Daly; Chinh Dang; Suvro Datta; Nick Dee; Tim A Dolbeare; Vance Faber; David Feng; David R Fowler; Jeff Goldy; Benjamin W Gregor; Zeb Haradon; David R Haynor; John G Hohmann; Steve Horvath; Robert E Howard; Andreas Jeromin; Jayson M Jochim; Marty Kinnunen; Christopher Lau; Evan T Lazarz; Changkyu Lee; Tracy A Lemon; Ling Li; Yang Li; John A Morris; Caroline C Overly; Patrick D Parker; Sheana E Parry; Melissa Reding; Joshua J Royall; Jay Schulkin; Pedro Adolfo Sequeira; Clifford R Slaughterbeck; Simon C Smith; Andy J Sodt; Susan M Sunkin; Beryl E Swanson; Marquis P Vawter; Derric Williams; Paul Wohnoutka; H Ronald Zielke; Daniel H Geschwind; Patrick R Hof; Stephen M Smith; Christof Koch; Seth G N Grant; Allan R Jones
Journal:  Nature       Date:  2012-09-20       Impact factor: 49.962
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  2 in total

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Authors:  Melissa Scholefield; Stephanie J Church; Jingshu Xu; Stefano Patassini; Federico Roncaroli; Nigel M Hooper; Richard D Unwin; Garth J S Cooper
Journal:  Front Mol Neurosci       Date:  2021-10-22       Impact factor: 5.639

2.  A spotter's guide to SNPtic exons: The common splice variants underlying some SNP-phenotype correlations.

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Journal:  Mol Genet Genomic Med       Date:  2021-10-28       Impact factor: 2.183
  2 in total

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