Literature DB >> 28868553

Origins of the enhanced affinity of RNA-protein interactions triggered by RNA phosphorodithioate backbone modification.

Xianbin Yang1, N Dinuka Abeydeera, Feng-Wu Liu, Martin Egli.   

Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA-protein interactions triggered by the PS2 moiety.

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Year:  2017        PMID： 28868553      PMCID： PMC5608642          DOI： 10.1039/c7cc05722a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  27 in total

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4.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

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Journal:  Nature       Date:  2001-05-24       Impact factor: 49.962

5.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.

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Journal:  Nature       Date:  2004-11-11       Impact factor: 49.962

6.  Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions.

Authors:  Xianbin Yang; Malgorzata Sierant; Magdalena Janicka; Lukasz Peczek; Carlos Martinez; Tom Hassell; Na Li; Xin Li; Tianzhi Wang; Barbara Nawrot
Journal:  ACS Chem Biol       Date:  2012-04-26       Impact factor: 5.100

Review 7.  Pervasive roles of microRNAs in cardiovascular biology.

Authors:  Eric M Small; Eric N Olson
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

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Authors:  Levani Zandarashvili; Dan Nguyen; Kurtis M Anderson; Mark A White; David G Gorenstein; Junji Iwahara
Journal:  Biophys J       Date:  2015-09-01       Impact factor: 4.033

Review 9.  Aptamers as therapeutics.

Authors:  Anthony D Keefe; Supriya Pai; Andrew Ellington
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10.  Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

Authors:  N Dinuka Abeydeera; Martin Egli; Nehemiah Cox; Karen Mercier; Jonas Nascimento Conde; Pradeep S Pallan; Daniella M Mizurini; Malgorzata Sierant; Fatima-Ezzahra Hibti; Tom Hassell; Tianzhi Wang; Feng-Wu Liu; Hong-Min Liu; Carlos Martinez; Anil K Sood; Terry P Lybrand; Chiraz Frydman; Robson Q Monteiro; Richard H Gomer; Barbara Nawrot; Xianbin Yang
Journal:  Nucleic Acids Res       Date:  2016-08-26       Impact factor: 16.971
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Authors:  Rafal Dolot; Curtis H Lam; Malgorzata Sierant; Qiang Zhao; Feng-Wu Liu; Barbara Nawrot; Martin Egli; Xianbin Yang
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2.  One Way Traffic: Base-to-Backbone Hole Transfer in Nucleoside Phosphorodithioate.

Authors:  Renata Kaczmarek; Samuel Ward; Dipra Debnath; Taisiya Jacobs; Alexander D Stark; Dariusz Korczyński; Anil Kumar; Michael D Sevilla; Sergey A Denisov; Viacheslav Shcherbakov; Pascal Pernot; Mehran Mostafavi; Roman Dembinski; Amitava Adhikary
Journal:  Chemistry       Date:  2020-06-09       Impact factor: 5.236

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Authors:  Jörg Duschmalé; Adrian Schäublin; Erik Funder; Steffen Schmidt; Łukasz J Kiełpiński; Helle Nymark; Klaus Jensen; Troels Koch; Martina Duschmalé; Erich Koller; Marianne Ravn Møller; Simone Schadt; Christophe Husser; Andreas Brink; Sabine Sewing; Tanja Minz; Jesper Wengel; Konrad Bleicher; Meiling Li
Journal:  Mol Ther Nucleic Acids       Date:  2022-06-22       Impact factor: 10.183

4.  Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts.

Authors:  Kazuhiko Yamasaki; Yukie Akutsu; Tomoko Yamasaki; Makoto Miyagishi; Tomomi Kubota
Journal:  Nucleic Acids Res       Date:  2020-05-07       Impact factor: 16.971
  4 in total

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