Literature DB >> 28868350

The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance.

Nadine Royla1, Stefan Kempa1.   

Abstract

Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3' untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.

Entities:  

Keywords:  Drug resistance; cancer metabolism; glutamine; post-transcriptional regulation

Year:  2017        PMID： 28868350      PMCID： PMC5540213          DOI： 10.1080/23723556.2017.1338209

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Induction of apoptosis in fibroblasts by c-myc protein.

Authors:  G I Evan; A H Wyllie; C S Gilbert; T D Littlewood; H Land; M Brooks; C M Waters; L Z Penn; D C Hancock
Journal:  Cell       Date:  1992-04-03       Impact factor: 41.582

2.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction.

Authors:  David R Wise; Ralph J DeBerardinis; Anthony Mancuso; Nabil Sayed; Xiao-Yong Zhang; Harla K Pfeiffer; Ilana Nissim; Evgueni Daikhin; Marc Yudkoff; Steven B McMahon; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-24       Impact factor: 11.205

Review 3.  MYC, PARP1, and chemoresistance: BIN there, done that?

Authors:  Shridar Ganesan
Journal:  Sci Signal       Date:  2011-03-29       Impact factor: 8.192

Review 4.  Therapeutic targeting of Myc-reprogrammed cancer cell metabolism.

Authors:  C V Dang
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2011-09-29

Review 5.  MYC, Metabolic Synthetic Lethality, and Cancer.

Authors:  Annie L Hsieh; Chi V Dang
Journal:  Recent Results Cancer Res       Date:  2016

Review 6.  MicroRNAs as regulators and mediators of c-MYC function.

Authors:  Rene Jackstadt; Heiko Hermeking
Journal:  Biochim Biophys Acta       Date:  2014-04-13

7.  Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation.

Authors:  Alex J Bott; I-Chen Peng; Yongjun Fan; Brandon Faubert; Lu Zhao; Jinyu Li; Sarah Neidler; Yu Sun; Nadia Jaber; Dawid Krokowski; Wenyun Lu; Ji-An Pan; Scott Powers; Joshua Rabinowitz; Maria Hatzoglou; Daniel J Murphy; Russell Jones; Song Wu; Geoffrey Girnun; Wei-Xing Zong
Journal:  Cell Metab       Date:  2015-10-23       Impact factor: 27.287

8.  Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal.

Authors:  Lan Liu; Miao Ouyang; Jaladanki N Rao; Tongtong Zou; Lan Xiao; Hee Kyoung Chung; Jing Wu; James M Donahue; Myriam Gorospe; Jian-Ying Wang
Journal:  Mol Biol Cell       Date:  2015-03-25       Impact factor: 4.138

Review 9.  Cap-Independent Translational Control of Carcinogenesis.

Authors:  Beth Walters; Sunnie R Thompson
Journal:  Front Oncol       Date:  2016-05-25       Impact factor: 6.244
  9 in total

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