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Literature DB >> 28868340

E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone.

Abstract

E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches. Small-molecule inhibitors blocked metastatic entry and mobilized established disease from BM, suggesting a new treatment strategy to prevent breast cancer relapse.

Entities: Disease Gene

Keywords: AMD-3100; E-selectin; GMI-1271; SDF-1; bone metastasis; breast cancer

Year: 2016 PMID： 28868340 PMCID： PMC5540205 DOI： 10.1080/23723556.2016.1214771

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

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7. A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.

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Journal: Sci Transl Med Date: 2016-05-25 Impact factor: 17.956