PURPOSE: This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma. METHODS: Clinical and histopathological examination of the pigmented conjunctival lesions was performed. RESULTS: A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following intravitreal anti-vascular endothelial growth factor (VEGF) injections, 2 pigmented conjunctival spots appeared at the injection sites. After excision of the lesions, histopathology showed pigment-loaded macrophages, with no signs of active tumour cells. CONCLUSION: Two conjunctival lesions that appeared following uveal melanoma brachytherapy and anti-VEGF injections were excised under suspicion of tumour seeding. Histopathology, however, showed aggregates of pigment-loaded macrophages.
PURPOSE: This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma. METHODS: Clinical and histopathological examination of the pigmented conjunctival lesions was performed. RESULTS: A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following intravitreal anti-vascular endothelial growth factor (VEGF) injections, 2 pigmented conjunctival spots appeared at the injection sites. After excision of the lesions, histopathology showed pigment-loaded macrophages, with no signs of active tumour cells. CONCLUSION: Two conjunctival lesions that appeared following uveal melanoma brachytherapy and anti-VEGF injections were excised under suspicion of tumour seeding. Histopathology, however, showed aggregates of pigment-loaded macrophages.
Authors: Lisa Tarmann; Werner Wackernagel; Alexander Avian; Christoph Mayer; Mona Schneider; Peter Winkler; Gerald Langmann Journal: Br J Ophthalmol Date: 2015-05-15 Impact factor: 4.638
Authors: Bertil Damato; Imran Patel; Ian R Campbell; Helen M Mayles; R Douglas Errington Journal: Int J Radiat Oncol Biol Phys Date: 2005-10-01 Impact factor: 7.038
Authors: Amy C Schefler; Daniel Gologorsky; Brian P Marr; Carol L Shields; Ignacio Zeolite; David H Abramson Journal: JAMA Ophthalmol Date: 2013-09 Impact factor: 7.389