Literature DB >> 28868212

High-Density Mapping of Brain Slices using a Large Multi-Functional High-Density CMOS Microelectrode Array System.

Vijay Viswam1, Raziyeh Bounik1, Amir Shadmani1, Jelena Dragas1, Marie Obien1,2, Jan Müller1,2, Yihui Chen1,3, Andreas Hierlemann1.   

Abstract

We present a CMOS-based high-density microelectrode array (HD-MEA) system that enables high-density mapping of brain slices in-vitro with multiple readout modalities. The 4.48×2.43 mm2 array consists of 59,760 micro-electrodes at 13.5 µm pitch (5487 electrodes/mm2). The overall system features 2048 action-potential, 32 local-field-potential and 32 current recording channels, 32 impedance-measurement and 28 neurotransmitter-detection channels and 16 voltage/current stimulation channels. The system enables real-time and label-free monitoring of position, size, morphology and electrical activity of brain slices.

Entities:  

Keywords:  Action potential; Brain slices; CMOS; Electrophysiology; High-density microelectrode arrays; Impedance measurement

Year:  2017        PMID： 28868212      PMCID： PMC5580803          DOI： 10.1109/TRANSDUCERS.2017.7994006

Source DB:  PubMed          Journal:  Int Solid State Sens Actuators Microsyst Conf        ISSN： 2167-0021


  6 in total

1.  Drug evaluations using neuronal networks cultured on microelectrode arrays.

Authors:  S I Morefield; E W Keefer; K D Chapman; G W Gross
Journal:  Biosens Bioelectron       Date:  2000-10       Impact factor: 10.618

2.  A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening.

Authors:  Taiyun Chi; Jong Seok Park; Jessica C Butts; Tracy A Hookway; Amy Su; Chengjie Zhu; Mark P Styczynski; Todd C McDevitt; Hua Wang
Journal:  IEEE Trans Biomed Circuits Syst       Date:  2016-01-22       Impact factor: 3.833

3.  Electrical conductivity in cat cerebellar cortex.

Authors:  M Yedlin; H Kwan; J T Murphy; H Nguyen-Huu; Y C Wong
Journal:  Exp Neurol       Date:  1974-06       Impact factor: 5.330

4.  Origin of the apparent tissue conductivity in the molecular and granular layers of the in vitro turtle cerebellum and the interpretation of current source-density analysis.

Authors:  Y C Okada; J C Huang; M E Rice; D Tranchina; C Nicholson
Journal:  J Neurophysiol       Date:  1994-08       Impact factor: 2.714

5.  A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro.

Authors:  Marco Ballini; Jan Müller; Paolo Livi; Yihui Chen; Urs Frey; Alexander Stettler; Amir Shadmani; Vijay Viswam; Ian Lloyd Jones; David Jäckel; Milos Radivojevic; Marta K Lewandowska; Wei Gong; Michele Fiscella; Douglas J Bakkum; Flavio Heer; Andreas Hierlemann
Journal:  IEEE J Solid-State Circuits       Date:  2014-11       Impact factor: 5.013

Review 6.  Revealing neuronal function through microelectrode array recordings.

Authors:  Marie Engelene J Obien; Kosmas Deligkaris; Torsten Bullmann; Douglas J Bakkum; Urs Frey
Journal:  Front Neurosci       Date:  2015-01-06       Impact factor: 4.677
  6 in total
  3 in total

1.  Xenon LFP Analysis Platform Is a Novel Graphical User Interface for Analysis of Local Field Potential From Large-Scale MEA Recordings.

Authors:  Arjun Mahadevan; Neela K Codadu; R Ryley Parrish
Journal:  Front Neurosci       Date:  2022-07-01       Impact factor: 5.152

2.  Assessing the Feasibility of Developing in vivo Neuroprobes for Parallel Intracellular Recording and Stimulation: A Perspective.

Authors:  Micha E Spira; Hadas Erez; Aviv Sharon
Journal:  Front Neurosci       Date:  2022-01-25       Impact factor: 4.677

3.  Multisite Attenuated Intracellular Recordings by Extracellular Multielectrode Arrays, a Perspective.

Authors:  Micha E Spira; Nava Shmoel; Shun-Ho M Huang; Hadas Erez
Journal:  Front Neurosci       Date:  2018-04-10       Impact factor: 4.677
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.