Literature DB >> 28867926

Quantum dot light emitting devices for photomedical applications.

Hao Chen1, Juan He2, Raymond Lanzafame3, Istvan Stadler4, Hamid El Hamidi5, Hui Liu5, Jonathan Celli5, Michael R Hamblin6, Yingying Huang6, Emily Oakley7, Gal Shafirstein7, Ho-Kyoon Chung8, Shin-Tson Wu2, Yajie Dong9.   

Abstract

While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large-area luminaire, photomedical researchers have been in search of low-cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in-vitro study to demonstrate that this QLED-based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength-specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED-based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.

Entities:  

Keywords:  photobiomodulation; photodynamic therapy; photomedicine; quantum dot light emitting devices (QLEDs)

Year:  2017        PMID: 28867926      PMCID: PMC5576728          DOI: 10.1002/jsid.543

Source DB:  PubMed          Journal:  J Soc Inf Disp        ISSN: 1071-0922            Impact factor:   2.140


  10 in total

1.  Efficiency roll-off in organic light-emitting diodes.

Authors:  Caroline Murawski; Karl Leo; Malte C Gather
Journal:  Adv Mater       Date:  2013-09-09       Impact factor: 30.849

2.  High-tech bandages lighten the load of light therapy.

Authors:  Jon Evans
Journal:  Nat Med       Date:  2009-07       Impact factor: 53.440

3.  Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia.

Authors:  Gal Shafirstein; Adva Friedman; Eric Siegel; Mauricio Moreno; Wolfgang Bäumler; Chun-Yang Fan; Kimberly Morehead; Emre Vural; Brendan C Stack; James Y Suen
Journal:  Arch Otolaryngol Head Neck Surg       Date:  2011-11

4.  Human skin wounds: a major and snowballing threat to public health and the economy.

Authors:  Chandan K Sen; Gayle M Gordillo; Sashwati Roy; Robert Kirsner; Lynn Lambert; Thomas K Hunt; Finn Gottrup; Geoffrey C Gurtner; Michael T Longaker
Journal:  Wound Repair Regen       Date:  2009 Nov-Dec       Impact factor: 3.617

Review 5.  Photodynamic Therapy of Non-Small Cell Lung Cancer. Narrative Review and Future Directions.

Authors:  Gal Shafirstein; Athar Battoo; Kassem Harris; Heinz Baumann; Sandra O Gollnick; Joerg Lindenmann; Chukwumere E Nwogu
Journal:  Ann Am Thorac Soc       Date:  2016-02

6.  Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide a for cancer of the oral cavity.

Authors:  Nestor Rigual; Gal Shafirstein; Michele T Cooper; Heinz Baumann; David A Bellnier; Ulas Sunar; Erin C Tracy; Daniel J Rohrbach; Gregory Wilding; Wei Tan; Maureen Sullivan; Mihai Merzianu; Barbara W Henderson
Journal:  Clin Cancer Res       Date:  2013-10-02       Impact factor: 12.531

7.  Photodynamic therapy with 3-(1'-hexyloxyethyl) pyropheophorbide-a for early-stage cancer of the larynx: Phase Ib study.

Authors:  Gal Shafirstein; Nestor R Rigual; Hassan Arshad; Michele T Cooper; David A Bellnier; Gregory Wilding; Wei Tan; Mihai Merzianu; Barbara W Henderson
Journal:  Head Neck       Date:  2015-06-29       Impact factor: 3.147

8.  Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models.

Authors:  Joshua Hempstead; Dustin P Jones; Abdelali Ziouche; Gwendolyn M Cramer; Imran Rizvi; Stephen Arnason; Tayyaba Hasan; Jonathan P Celli
Journal:  Sci Rep       Date:  2015-05-12       Impact factor: 4.379

9.  A new finite element approach for near real-time simulation of light propagation in locally advanced head and neck tumors.

Authors:  Emily Oakley; Brian Wrazen; David A Bellnier; Yusef Syed; Hassan Arshad; Gal Shafirstein
Journal:  Lasers Surg Med       Date:  2015-01-05       Impact factor: 4.025

10.  Current state and future of photodynamic therapy for the treatment of head and neck squamous cell carcinoma.

Authors:  Christina Mimikos; Gal Shafirstein; Hassan Arshad
Journal:  World J Otorhinolaryngol Head Neck Surg       Date:  2016-07-01
  10 in total
  1 in total

1.  Flexible quantum dot light-emitting devices for targeted photomedical applications.

Authors:  Hao Chen; Tzu-Hung Yeh; Juan He; Caicai Zhang; Robert Abbel; Michael R Hamblin; Yingying Huang; Raymond J Lanzafame; Istvan Stadler; Jonathan Celli; Shun-Wei Liu; Shin-Tson Wu; Yajie Dong
Journal:  J Soc Inf Disp       Date:  2018-05-04       Impact factor: 2.140

  1 in total

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