Luca Boeri1, Paolo Capogrosso2, Eugenio Ventimiglia2, Walter Cazzaniga2, Filippo Pederzoli2, Giorgio Gandaglia2, Nadia Finocchio3, Federico Dehò3, Alberto Briganti2, Emanuele Montanari4, Francesco Montorsi2, Andrea Salonia5. 1. Unit of Urology, Division of Experimental Oncology, Istituto di Ricerca Urologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Milan, Italy; Department of Urology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Ca' Granda-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. 2. Unit of Urology, Division of Experimental Oncology, Istituto di Ricerca Urologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy. 3. Unit of Urology, Division of Experimental Oncology, Istituto di Ricerca Urologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Milan, Italy. 4. Department of Urology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Ca' Granda-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy. 5. Unit of Urology, Division of Experimental Oncology, Istituto di Ricerca Urologica, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Raffaele, Milan, Italy; University Vita-Salute San Raffaele, Milan, Italy. Electronic address: salonia.andrea@hsr.it.
Abstract
PURPOSE: We assessed the rate and predictors of depressive symptoms and impaired sexual desire in patients who underwent open or robot-assisted radical prostatectomy. MATERIALS AND METHODS: A total of 811 patients completed IIEF (International Index of Erectile Function) and BDI (Beck Depression Inventory) preoperatively, and 6, 12, 24 and 36 months postoperatively. Rates and predictors of depressive symptoms and impaired sexual desire were assessed with descriptive statistics and logistic regression models. RESULTS: We analyzed data on 416 patients treated with robot-assisted radical prostatectomy and 395 who underwent open radical prostatectomy. Overall the incidence of patients with postoperative BDI scores suggestive of depressive symptoms ranged between 26.3% at 6 months and 36.7% at 36 months. BDI scores were significantly higher in open than in robot-assisted radical prostatectomy cases at every analyzed postoperative time point (all p <0.01). Patients treated with robot-assisted radical prostatectomy showed higher IIEF-EF (Erectile Function) domain scores and a greater proportion of them experienced erectile function recovery at each time point compared to those treated with open radical prostatectomy (all p <0.005). Postoperatively the rate of impaired sexual desire ranged between 40.9% at 6 months and 34.1% at 24 months. IIEF-SD (Sexual Domain) scores were significantly lower in open radical prostatectomy cases at every followup (all p <0.02). Age, open radical prostatectomy and postoperative erectile dysfunction were independent predictors of BDI scores and impaired sexual desire. CONCLUSIONS: One of 3 men surgically treated for prostate cancer still report depressive symptoms months after surgery. Patients who undergo robot-assisted radical prostatectomy reported lower depressive symptoms than those treated with open radical prostatectomy. Sexual desire was highly affected after radical prostatectomy with greater impairment reported by patients who underwent open radical prostatectomy.
PURPOSE: We assessed the rate and predictors of depressive symptoms and impaired sexual desire in patients who underwent open or robot-assisted radical prostatectomy. MATERIALS AND METHODS: A total of 811 patients completed IIEF (International Index of Erectile Function) and BDI (Beck Depression Inventory) preoperatively, and 6, 12, 24 and 36 months postoperatively. Rates and predictors of depressive symptoms and impaired sexual desire were assessed with descriptive statistics and logistic regression models. RESULTS: We analyzed data on 416 patients treated with robot-assisted radical prostatectomy and 395 who underwent open radical prostatectomy. Overall the incidence of patients with postoperative BDI scores suggestive of depressive symptoms ranged between 26.3% at 6 months and 36.7% at 36 months. BDI scores were significantly higher in open than in robot-assisted radical prostatectomy cases at every analyzed postoperative time point (all p <0.01). Patients treated with robot-assisted radical prostatectomy showed higher IIEF-EF (Erectile Function) domain scores and a greater proportion of them experienced erectile function recovery at each time point compared to those treated with open radical prostatectomy (all p <0.005). Postoperatively the rate of impaired sexual desire ranged between 40.9% at 6 months and 34.1% at 24 months. IIEF-SD (Sexual Domain) scores were significantly lower in open radical prostatectomy cases at every followup (all p <0.02). Age, open radical prostatectomy and postoperative erectile dysfunction were independent predictors of BDI scores and impaired sexual desire. CONCLUSIONS: One of 3 men surgically treated for prostate cancer still report depressive symptoms months after surgery. Patients who undergo robot-assisted radical prostatectomy reported lower depressive symptoms than those treated with open radical prostatectomy. Sexual desire was highly affected after radical prostatectomy with greater impairment reported by patients who underwent open radical prostatectomy.
Authors: Edoardo Pozzi; Paolo Capogrosso; Luca Boeri; Walter Cazzaniga; Rayan Matloob; Eugenio Ventimiglia; Davide Oreggia; Nicolò Schifano; Luigi Candela; Costantino Abbate; Francesco Montorsi; Andrea Salonia Journal: Int J Impot Res Date: 2020-07-01 Impact factor: 2.896
Authors: Alicja Popiołek; Bartosz Brzoszczyk; Piotr Jarzemski; Małgorzata Piskunowicz; Marcin Jarzemski; Alina Borkowska; Maciej Bieliński Journal: Cancer Manag Res Date: 2022-05-20 Impact factor: 3.602
Authors: Catherine E Lovegrove; Vincenzo Ficarra; Francesco Montorsi; James N'Dow; Andrea Salonia; Suks Minhas Journal: Int J Impot Res Date: 2019-12-13 Impact factor: 2.896