| Literature DB >> 2886715 |
H S Pall, A C Williams, D R Blake, J Lunec, J M Gutteridge, M Hall, A Taylor.
Abstract
The cerebrospinal-fluid copper concentration, measured by electrothermal atomisation/atomic absorption spectrophotometry, was significantly higher in 24 patients with untreated, idiopathic Parkinson's disease than in a control population of 34 patients (p less than 0.001). The difference in the in-vitro capacity of copper to damage DNA, measured by the phenanthroline assay was even greater. The high phenanthroline-copper concentration correlated with disease severity (p = 0.02) and with the rate of progression of disease (p less than 0.05). A possible role is suggested for copper-catalysed oxidative mechanisms in the pathogenesis of Parkinson's disease.Entities:
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Year: 1987 PMID： 2886715 DOI： 10.1016/s0140-6736(87)90827-0
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321