Domenico Lepore1, Graham E Quinn2, Fernando Molle3, Lorenzo Orazi3, Antonio Baldascino3, Marco H Ji3, Maria Sammartino4, Fabio Sbaraglia4, Daniela Ricci5, Eugenio Mercuri5. 1. Department of Ophthalmology, Catholic University of Sacred Heart, Rome, Italy. Electronic address: domenico.lepore@unicatt.it. 2. Division of Pediatric Ophthalmology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. 3. Department of Ophthalmology, Catholic University of Sacred Heart, Rome, Italy. 4. Department of Anesthesiology, Catholic University of Sacred Heart, Rome, Italy. 5. Department of Pediatric Neurology, Catholic University of Sacred Heart, Rome, Italy.
Abstract
PURPOSE: To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablationin type 1 retinopathy of prematurity (ROP). DESIGN: Single, randomized, controlled trial. PARTICIPANTS: All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. METHODS: In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0.5 mg bevacizumab; the fellow eye underwent conventional laser photoablation. Digital retinal imaging and fluorescein angiography (FA) were performed at an average of 4 years after treatment in follow-up after these studies performed at treatment and 9 months. MAIN OUTCOME MEASURES: Fluorescein angiograms were examined by 2 experts to document retinal and choroidal findings. RESULTS: Among the 20 bevacizumab-treated eyes available at 4 years of age, all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel branching, and tangles) or the posterior pole (hyperfluorescent lesions, absence of foveal avascular zone). These lesions were not observed in the majority of the lasered eyes. Among the 19 laser-treated eyes, leakage was noted in 1 eye, shunts and tangles were noted in 3 eyes, and macular abnormalities were noted in 3 eyes. CONCLUSIONS:Fluorescein angiography has shown potentially serious and long-term ocular effects that are present more commonly after treatment with bevacizumab for acute-phase ROP than after laser.
RCT Entities:
PURPOSE: To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablation in type 1 retinopathy of prematurity (ROP). DESIGN: Single, randomized, controlled trial. PARTICIPANTS: All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. METHODS: In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0.5 mg bevacizumab; the fellow eye underwent conventional laser photoablation. Digital retinal imaging and fluorescein angiography (FA) were performed at an average of 4 years after treatment in follow-up after these studies performed at treatment and 9 months. MAIN OUTCOME MEASURES: Fluorescein angiograms were examined by 2 experts to document retinal and choroidal findings. RESULTS: Among the 20 bevacizumab-treated eyes available at 4 years of age, all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel branching, and tangles) or the posterior pole (hyperfluorescent lesions, absence of foveal avascular zone). These lesions were not observed in the majority of the lasered eyes. Among the 19 laser-treated eyes, leakage was noted in 1 eye, shunts and tangles were noted in 3 eyes, and macular abnormalities were noted in 3 eyes. CONCLUSIONS:Fluorescein angiography has shown potentially serious and long-term ocular effects that are present more commonly after treatment with bevacizumab for acute-phase ROP than after laser.
Authors: Sasha A Mansukhani; Amy K Hutchinson; Rebecca Neustein; Joseph Schertzer; John C Allen; G Baker Hubbard Journal: Ophthalmol Retina Date: 2019-01-31
Authors: Abdualrahman E Hamad; Omar Moinuddin; Michael P Blair; Sidney A Schechet; Michael J Shapiro; Polly A Quiram; Danny A Mammo; Audina M Berrocal; Supalert Prakhunhungsit; Linda A Cernichiaro-Espinosa; Shizuo Mukai; Yoshihiro Yonekawa; Cindy Ung; Eric R Holz; C Armitage Harper; Ryan C Young; Cagri G Besirli; Aaron Nagiel; Thomas C Lee; Mrinali P Gupta; Mark K Walsh; Joseph A Khawly; J Peter Campbell; Andres Kychenthal; Eric D Nudleman; Josh E Robinson; Mary Elizabeth Hartnett; Charles M Calvo; Emmanuel Y Chang Journal: Ophthalmol Retina Date: 2019-12-24
Authors: Christopher M Schafer; Jami M Gurley; Katarzyna Kurylowicz; Prisca K Lin; Wen Chen; Michael H Elliott; George E Davis; Faizah Bhatti; Courtney T Griffin Journal: Proc Natl Acad Sci U S A Date: 2020-10-05 Impact factor: 11.205