Yue-Qin Xu1, Gui-Mei Li2, Yan Li3. 1. Shandong Provincial Hospital Affiliated to Shandong University, Department of Pediatrics, 9677 Jinshi Road, Jinan 250014, China; Shandong Qianfoshan Hospital Affiliated to Shandong University, Department of Children Healthcare, 16766 Jinshi Road, Jinan 250014, China. 2. Shandong Provincial Hospital Affiliated to Shandong University, Department of Pediatrics, 9677 Jinshi Road, Jinan 250014, China. Electronic address: liguimei0531@126.com. 3. Shandong Qianfoshan Hospital Affiliated to Shandong University, Department of Children Healthcare, 16766 Jinshi Road, Jinan 250014, China.
Abstract
OBJECTIVE: Diagnosis of central precocious puberty has always been challenging in clinical practice. As an important method in the diagnosis of central precocious puberty, luteinizing hormone-releasing hormone stimulation test is complex and time-consuming. In many cases, clinical traits are inconsistent with luteinizing hormone-releasing hormone stimulation test results, therefore not reliable for diagnosis. In this study, the authors intended to find an indicator that predicts the results of the luteinizing hormone-releasing hormone stimulation test among subjects with early pubertal signs. METHODS: Cases of 382 girls with early breast development before 8 years old and luteinizing hormone-releasing hormone stimulation test before 9 years old were included and underwent follow-up tests. Patients with peak luteinizing hormone level ≥5IU/L were considered positive in the luteinizing hormone-releasing hormone stimulation test. Anthropometric data, body mass index, bone age evaluation, blood hormones levels of luteinizing hormone, estradiol, follicle-stimulating hormone, and uterine and ovarian volumes were analyzed. RESULTS: Subjects with positive results in the initial test demonstrated early bone maturation, accelerated growth, and elevated basal blood luteinizing hormone, estradiol, and follicle-stimulating hormone levels, when compared with subjects with negative results in the initial test. Subjects with positive results in the follow-up test presented a more advanced bone age and more accelerated linear growth, when compared with subjects with negative results in the follow-up test. CONCLUSIONS: According to the statistical analysis, advanced bone age is the most effective predictor of the result of luteinizing hormone-releasing hormone stimulation test.
OBJECTIVE: Diagnosis of central precocious puberty has always been challenging in clinical practice. As an important method in the diagnosis of central precocious puberty, luteinizing hormone-releasing hormone stimulation test is complex and time-consuming. In many cases, clinical traits are inconsistent with luteinizing hormone-releasing hormone stimulation test results, therefore not reliable for diagnosis. In this study, the authors intended to find an indicator that predicts the results of the luteinizing hormone-releasing hormone stimulation test among subjects with early pubertal signs. METHODS: Cases of 382 girls with early breast development before 8 years old and luteinizing hormone-releasing hormone stimulation test before 9 years old were included and underwent follow-up tests. Patients with peak luteinizing hormone level ≥5IU/L were considered positive in the luteinizing hormone-releasing hormone stimulation test. Anthropometric data, body mass index, bone age evaluation, blood hormones levels of luteinizing hormone, estradiol, follicle-stimulating hormone, and uterine and ovarian volumes were analyzed. RESULTS: Subjects with positive results in the initial test demonstrated early bone maturation, accelerated growth, and elevated basal blood luteinizing hormone, estradiol, and follicle-stimulating hormone levels, when compared with subjects with negative results in the initial test. Subjects with positive results in the follow-up test presented a more advanced bone age and more accelerated linear growth, when compared with subjects with negative results in the follow-up test. CONCLUSIONS: According to the statistical analysis, advanced bone age is the most effective predictor of the result of luteinizing hormone-releasing hormone stimulation test.
Keywords:
Bone age; Central precocious puberty; Growth velocity; Idade óssea; Luteinizing hormone-releasing hormone stimulation test; Puberdade precoce central; Teste de estimulação do hormônio liberador do hormônio luteinizante; Velocidade de crescimento
Authors: Quynh Thi Vu Huynh; Nguyen Quoc Khanh Le; Shih-Yi Huang; Ban Tran Ho; Tru Huy Vu; Hong Thi Minh Pham; An Le Pham; Jia-Woei Hou; Ngan Thi Kim Nguyen; Yang Ching Chen Journal: PLoS One Date: 2022-01-21 Impact factor: 3.240