Literature DB >> 2886630

Mean residence time for drugs subject to reversible metabolism.

L Aarons.   

Abstract

Conventional methods based on moment analysis lead to biased estimates of the mean residence time for drugs subject to reversible metabolism. A stochastic approach is described which enables unbiased estimation of the mean residence time.

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Year:  1987        PMID： 2886630     DOI： 10.1111/j.2042-7158.1987.tb03181.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  7 in total

Review 1.  Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).

Authors:  P Veng-Pedersen
Journal:  Clin Pharmacokinet       Date:  1989-12       Impact factor: 6.447

2.  An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment.

Authors:  E Nakashima; L Z Benet
Journal:  J Pharmacokinet Biopharm       Date:  1989-12

3.  Nonlinear pharmacokinetics and interconversion of prednisolone and prednisone in rats.

Authors:  M L Huang; W J Jusko
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

4.  Mean residence times and distribution volumes for drugs undergoing linear reversible metabolism and tissue distribution and linear or nonlinear elimination from the central compartments.

Authors:  H Y Cheng; W J Jusko
Journal:  Pharm Res       Date:  1991-04       Impact factor: 4.200

5.  Mean interconversion times and distribution rate parameters for drugs undergoing reversible metabolism.

Authors:  H Y Cheng; W J Jusko
Journal:  Pharm Res       Date:  1990-10       Impact factor: 4.200

6.  Constant-rate intravenous infusion methods for estimating steady-state volumes of distribution and mean residence times in the body for drugs undergoing reversible metabolism.

Authors:  H Cheng; W J Jusko
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

Review 7.  Mean residence time of oral drugs undergoing first-pass and linear reversible metabolism.

Authors:  H Cheng; W J Jusko
Journal:  Pharm Res       Date:  1993-01       Impact factor: 4.200
  7 in total

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