Literature DB >> 28866063

Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.

Keisuke Takai1, Shota Tanaka2, Takashi Sota3, Akitake Mukasa2, Takashi Komori4, Makoto Taniguchi3.   

Abstract

BACKGROUND: In 2016, the World Health Organization updated its classification of tumors, adding genetic profiles to the conventional histopathologic typing. CASE DESCRIPTION: The authors present herein the first case of a 44-year-old female with isocitrate dehydrogenase-mutant World Health Organization grade II diffuse spinal astrocytoma diagnosed on the basis of both histopathologic and genetic findings.
CONCLUSIONS: The present case underscores the significant role of a molecular genetic analysis in the differential diagnosis of intramedullary spinal gliomas.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Astrocytoma; Glioma; H3-K27M; IDH1 gene; IDH2 gene; Intramedullary spinal cord tumor

Mesh：

Substances：

Year:  2017        PMID： 28866063     DOI： 10.1016/j.wneu.2017.08.142

Source DB:  PubMed          Journal:  World Neurosurg        ISSN： 1878-8750            Impact factor:   2.104


  7 in total

1.  Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors.

Authors:  Yoshitaka Nagashima; Yusuke Nishimura; Kaoru Eguchi; Junya Yamaguchi; Shoichi Haimoto; Fumiharu Ohka; Masakazu Takayasu; Ryuta Saito
Journal:  Neurospine       Date:  2022-05-16

2.  Molecular Biomarkers of Brain and Spinal Cord Astrocytomas.

Authors:  N A Konovalov; D S Asyutin; E G Shayhaev; S V Kaprovoy; S Yu Timonin
Journal:  Acta Naturae       Date:  2019 Apr-Jun       Impact factor: 1.845

3.  Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury.

Authors:  Yoshitaka Nagashima; Yusuke Nishimura; Fumiharu Ohka; Kaoru Eguchi; Kosuke Aoki; Hiroshi Ito; Tomoya Nishii; Takahiro Oyama; Masahito Hara; Yotaro Kitano; Hirano Masaki; Toshihiko Wakabayashi; Atsushi Natsume
Journal:  Cells       Date:  2021-09-24       Impact factor: 6.600

Review 4.  Surgical approaches to intramedullary spinal cord astrocytomas in the age of genomics.

Authors:  Andrew M Hersh; George I Jallo; Nir Shimony
Journal:  Front Oncol       Date:  2022-09-06       Impact factor: 5.738

5.  Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas.

Authors:  Annamaria Biczok; Felix L Strübing; Julia M Eder; Rupert Egensperger; Oliver Schnell; Stefan Zausinger; Julia E Neumann; Jochen Herms; Joerg-Christian Tonn; Mario M Dorostkar
Journal:  Acta Neuropathol Commun       Date:  2021-06-30       Impact factor: 7.801

6.  Clinical, radiological and molecular characterization of intramedullary astrocytomas.

Authors:  Laetitia Lebrun; Barbara Meléndez; Oriane Blanchard; Nancy De Nève; Claude Van Campenhout; Julie Lelotte; Danielle Balériaux; Matteo Riva; Jacques Brotchi; Michaël Bruneau; Olivier De Witte; Christine Decaestecker; Nicky D'Haene; Isabelle Salmon
Journal:  Acta Neuropathol Commun       Date:  2020-08-08       Impact factor: 7.801

7.  Analyses of DNA Methylation Profiling in the Diagnosis of Intramedullary Astrocytomas.

Authors:  Laetitia Lebrun; Martin Bizet; Barbara Melendez; Barbara Alexiou; Lara Absil; Claude Van Campenhout; Nicky D'Haene; Sandrine Rorive; François Fuks; Christine Decaestecker; Isabelle Salmon
Journal:  J Neuropathol Exp Neurol       Date:  2021-08-11       Impact factor: 3.685
  7 in total

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