Literature DB >> 2886587

A new method for measuring the free fraction of cyclosporin in plasma by equilibrium dialysis.

S Henricsson.   

Abstract

The free fraction of cyclosporin in plasma has been measured by equilibrium dialysis in steel chambers. Equilibration time was 16 h. The intra-assay coefficient of variation was 7%. The free fraction remained constant in plasma samples frozen for up to 6 months, and was independent of the total concentration within the therapeutic range.

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Year:  1987        PMID： 2886587     DOI： 10.1111/j.2042-7158.1987.tb03402.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  5 in total

1.  The binding of cyclosporin A to human plasma: an in vitro microdialysis study.

Authors:  H Yang; W F Elmquist
Journal:  Pharm Res       Date:  1996-04       Impact factor: 4.200

Review 2.  Methods for measuring aptamer-protein equilibria: a review.

Authors:  Meng Jing; Michael T Bowser
Journal:  Anal Chim Acta       Date:  2010-11-10       Impact factor: 6.558

Review 3.  Distribution of cyclosporin in organ transplant recipients.

Authors:  Fatemeh Akhlaghi; Andrew K Trull
Journal:  Clin Pharmacokinet       Date:  2002       Impact factor: 6.447

4.  Monitoring of the free concentration of cyclosporine in plasma in man.

Authors:  A Lindholm
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

5.  Intraindividual variability in the relative systemic availability of cyclosporin after oral dosing.

Authors:  A Lindholm; S Henricsson; M Lind; R Dahlqvist
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953
  5 in total

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