| Literature DB >> 28865392 |
Nora C Pyenson1, Luciano A Marraffini2.
Abstract
Type III CRISPR-Cas systems have a unique targeting mechanism that requires the transcription of the DNA target and results in the degradation of not only the genome of the invader but also its transcripts. Here we discuss the most recent studies describing dual DNA and RNA targeting by these systems, as well as the implications of this complex molecular mechanism for immunity in vivo.Mesh：
Year: 2017 PMID： 28865392 DOI： 10.1016/j.mib.2017.08.003
Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934