Ashley S Felix1, Cindy K Blair2,3, Amy Lehman4, Julie K Bower5, Subha V Raman6, DeAnn Lazovich7,8, David E Cohn9, Anna E Prizment7,8. 1. Division of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Avenue, 346 Cunz Hall, Columbus, OH, 43210, USA. Felix.20@osu.edu. 2. Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA. 3. University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. 4. Center for Biostatistics, The Ohio State University, Columbus, OH, USA. 5. Division of Epidemiology, College of Public Health, The Ohio State University, 1841 Neil Avenue, 346 Cunz Hall, Columbus, OH, 43210, USA. 6. Division of Cardiology, College of Medicine, The Ohio State University, Columbus, OH, USA. 7. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA. 8. Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA. 9. Division of Gynecologic Oncology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Abstract
PURPOSE: Obesity is associated with endometrial cancer (EC) development and cardiovascular disease (CVD) mortality. As the number of obese EC survivors continues to increase, an examination of CVD mortality in this vulnerable population is warranted. METHODS: In the Iowa Women's Health Study (1986-2011), we examined CVD mortality among 552 women with EC compared with 2,352 age- and body mass index-matched women without EC (controls). Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were estimated using multivariable-adjusted Cox proportional hazards regression models stratified by an indicator for match set. RESULTS: Compared to controls, women with EC more often reported a history of diabetes, hypertension, and never smoking. Compared with controls, women with EC had lower CVD mortality (HR 0.75, 95% CI 0.56-0.99), and higher all-cause mortality (HR 1.50, 95% CI 1.30-1.74). CONCLUSIONS: Although some CVD risk factors were more common in women with versus without EC, CVD mortality was lower among the former group. Additional well-adjusted analyses with larger study populations are needed to understand interactions between CVD risk factors with CVD mortality among EC survivors. The CVD risk factor profile of EC survivors warrants emphasis on cardiovascular health.
PURPOSE:Obesity is associated with endometrial cancer (EC) development and cardiovascular disease (CVD) mortality. As the number of obeseEC survivors continues to increase, an examination of CVD mortality in this vulnerable population is warranted. METHODS: In the Iowa Women's Health Study (1986-2011), we examined CVD mortality among 552 women with EC compared with 2,352 age- and body mass index-matched women without EC (controls). Hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD mortality were estimated using multivariable-adjusted Cox proportional hazards regression models stratified by an indicator for match set. RESULTS: Compared to controls, women with EC more often reported a history of diabetes, hypertension, and never smoking. Compared with controls, women with EC had lower CVD mortality (HR 0.75, 95% CI 0.56-0.99), and higher all-cause mortality (HR 1.50, 95% CI 1.30-1.74). CONCLUSIONS: Although some CVD risk factors were more common in women with versus without EC, CVD mortality was lower among the former group. Additional well-adjusted analyses with larger study populations are needed to understand interactions between CVD risk factors with CVD mortality among EC survivors. The CVD risk factor profile of EC survivors warrants emphasis on cardiovascular health.
Authors: W T Creasman; F Odicino; P Maisonneuve; M A Quinn; U Beller; J L Benedet; A P M Heintz; H Y S Ngan; S Pecorelli Journal: Int J Gynaecol Obstet Date: 2006-11 Impact factor: 3.561
Authors: Ashley S Felix; Julie K Bower; Ruth M Pfeiffer; Subha V Raman; David E Cohn; Mark E Sherman Journal: Int J Cancer Date: 2016-11-14 Impact factor: 7.396
Authors: B Anderson; J P Connor; J I Andrews; C S Davis; R E Buller; J I Sorosky; J A Benda Journal: Am J Obstet Gynecol Date: 1996-04 Impact factor: 8.661
Authors: Amy Berrington de Gonzalez; Patricia Hartge; James R Cerhan; Alan J Flint; Lindsay Hannan; Robert J MacInnis; Steven C Moore; Geoffrey S Tobias; Hoda Anton-Culver; Laura Beane Freeman; W Lawrence Beeson; Sandra L Clipp; Dallas R English; Aaron R Folsom; D Michal Freedman; Graham Giles; Niclas Hakansson; Katherine D Henderson; Judith Hoffman-Bolton; Jane A Hoppin; Karen L Koenig; I-Min Lee; Martha S Linet; Yikyung Park; Gaia Pocobelli; Arthur Schatzkin; Howard D Sesso; Elisabete Weiderpass; Bradley J Willcox; Alicja Wolk; Anne Zeleniuch-Jacquotte; Walter C Willett; Michael J Thun Journal: N Engl J Med Date: 2010-12-02 Impact factor: 91.245
Authors: Hannah Arem; Yikyung Park; Colleen Pelser; Rachel Ballard-Barbash; Melinda L Irwin; Albert Hollenbeck; Gretchen L Gierach; Louise A Brinton; Ruth M Pfeiffer; Charles E Matthews Journal: J Natl Cancer Inst Date: 2013-01-07 Impact factor: 13.506
Authors: Veronica Wendy Setiawan; Hannah P Yang; Malcolm C Pike; Susan E McCann; Herbert Yu; Yong-Bing Xiang; Alicja Wolk; Nicolas Wentzensen; Noel S Weiss; Penelope M Webb; Piet A van den Brandt; Koen van de Vijver; Pamela J Thompson; Brian L Strom; Amanda B Spurdle; Robert A Soslow; Xiao-ou Shu; Catherine Schairer; Carlotta Sacerdote; Thomas E Rohan; Kim Robien; Harvey A Risch; Fulvio Ricceri; Timothy R Rebbeck; Radhai Rastogi; Jennifer Prescott; Silvia Polidoro; Yikyung Park; Sara H Olson; Kirsten B Moysich; Anthony B Miller; Marjorie L McCullough; Rayna K Matsuno; Anthony M Magliocco; Galina Lurie; Lingeng Lu; Jolanta Lissowska; Xiaolin Liang; James V Lacey; Laurence N Kolonel; Brian E Henderson; Susan E Hankinson; Niclas Håkansson; Marc T Goodman; Mia M Gaudet; Montserrat Garcia-Closas; Christine M Friedenreich; Jo L Freudenheim; Jennifer Doherty; Immaculata De Vivo; Kerry S Courneya; Linda S Cook; Chu Chen; James R Cerhan; Hui Cai; Louise A Brinton; Leslie Bernstein; Kristin E Anderson; Hoda Anton-Culver; Leo J Schouten; Pamela L Horn-Ross Journal: J Clin Oncol Date: 2013-06-03 Impact factor: 44.544
Authors: Ashley S Felix; Amy Lehman; Randi E Foraker; Michelle J Naughton; Julie K Bower; Lewis Kuller; Gloria E Sarto; Marcia L Stefanick; Linda Van Horn; Rebecca D Jackson; Electra D Paskett Journal: Cancer Epidemiol Date: 2017-10-16 Impact factor: 2.984
Authors: Sarah J Kitson; Jennifer Lindsay; Vanitha N Sivalingam; Mark Lunt; Neil A J Ryan; Richard J Edmondson; Martin K Rutter; Emma J Crosbie Journal: Gynecol Oncol Date: 2017-11-24 Impact factor: 5.482