Literature DB >> 28864899

Detection of human neuronal α7 nicotinic acetylcholine receptors by conjugates of snake α-neurotoxin with quantum dots.

Ya V Makarova1, I V Shelukhina1, A K Mukherjee2, D V Kuznetsov3, V I Tsetlin1, Yu N Utkin4,5.   

Abstract

Fluorescent derivatives are widely used to study the structure and functions of proteins. Quantum dots (QDs), fluorescent semiconductor nanocrystals, have a high quantum yield and are much more resistant to bleaching compared to organic dyes. Conjugates of α-neurotoxins with QDs were used for visualization of human α7 acetylcholine receptors heterologously expressed in GH4C1 pituitary adenoma cells. Specific staining of cells by the conjugated toxins was observed.

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Year:  2017        PMID： 28864899     DOI： 10.1134/S1607672917040032

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  8 in total

1.  Orientation of cobra alpha-toxin on the nicotinic acetylcholine receptor. Fluorescence studies.

Authors:  D A Johnson; R Cushman; R Malekzadeh
Journal:  J Biol Chem       Date:  1990-05-05       Impact factor: 5.157

2.  Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release.

Authors:  David Gomez-Varela; Darwin K Berg
Journal:  J Neurosci       Date:  2013-10-23       Impact factor: 6.167

Review 3.  Alpha7 neuronal nicotinic receptor: a pluripotent target for diseases of the central nervous system.

Authors:  Merouane Bencherif; Sridhar T Narla; Michal S Stachowiak
Journal:  CNS Neurol Disord Drug Targets       Date:  2014       Impact factor: 4.388

4.  Presence of alpha7 nicotinic acetylcholine receptors on dorsal root ganglion neurons proved using knockout mice and selective alpha-neurotoxins in histochemistry.

Authors:  Irina V Shelukhina; Elena V Kryukova; Katrin Susanne Lips; Victor I Tsetlin; Wolfgang Kummer
Journal:  J Neurochem       Date:  2009-03-11       Impact factor: 5.372

5.  Single particle tracking of alpha7 nicotinic AChR in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites.

Authors:  Thomas Bürli; Kristin Baer; Helge Ewers; Corinne Sidler; Christian Fuhrer; Jean-Marc Fritschy
Journal:  PLoS One       Date:  2010-07-09       Impact factor: 3.240

6.  Interaction surfaces of neurotoxins and acetylcholine receptor.

Authors:  V I Tsetlin; E Karlsson; K A Pluzhnikov; A S Arseniev; A M Surin; V V Kondakov; V F Bystrov; V T Ivanov
Journal:  Toxicon       Date:  1982       Impact factor: 3.033

7.  Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.

Authors:  Yuri N Utkin; Christoph Weise; Igor E Kasheverov; Tatyana V Andreeva; Elena V Kryukova; Maxim N Zhmak; Vladislav G Starkov; Ngoc Anh Hoang; Daniel Bertrand; Joachim Ramerstorfer; Werner Sieghart; Andrew J Thompson; Sarah C R Lummis; Victor I Tsetlin
Journal:  J Biol Chem       Date:  2012-05-21       Impact factor: 5.157

Review 8.  Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways.

Authors:  Robert Zdanowski; Małgorzata Krzyżowska; Dominika Ujazdowska; Aneta Lewicka; Sławomir Lewicki
Journal:  Cent Eur J Immunol       Date:  2015-10-15       Impact factor: 2.085
  8 in total

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