Literature DB >> 28864897

New paradoxical three-finger toxin from the cobra Naja kaouthia venom: Isolation and characterization.

A V Osipov1, A V Meshcheryakova1,2, V G Starkov1, R Kh Ziganshin1, T L Oustitch3, L-E Peters3, V I Tsetlin1, Yu N Utkin4,5.   

Abstract

A new three-finger toxin nakoroxin was isolated from the cobra Naja kaouthia venom, and its complete amino acid sequence was established. Nakoroxin belongs to the group of "orphan" toxins, data on the biological activity of which are practically absent. Nakoroxin shows no cytotoxicity and does not inhibit the binding of α-bungarotoxin to nicotinic acetylcholine receptors of muscle and α7 types. However, it potentiates the binding of α-bungarotoxin to the acetylcholine-binding protein from Lymnaea stagnalis. This is the first toxin with such an unusual property.

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Year:  2017        PMID： 28864897     DOI： 10.1134/S1607672917040068

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  10 in total

Review 1.  Three-finger alpha-neurotoxins and the nicotinic acetylcholine receptor, forty years on.

Authors:  Selvanayagam Nirthanan; Matthew C E Gwee
Journal:  J Pharmacol Sci       Date:  2004-01       Impact factor: 3.337

2.  Molecular evolution and phylogeny of elapid snake venom three-finger toxins.

Authors:  B G Fry; W Wüster; R M Kini; V Brusic; A Khan; D Venkataraman; A P Rooney
Journal:  J Mol Evol       Date:  2003-07       Impact factor: 2.395

Review 3.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Authors:  S F Altschul; T L Madden; A A Schäffer; J Zhang; Z Zhang; W Miller; D J Lipman
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

Review 4.  Three-finger snake neurotoxins and Ly6 proteins targeting nicotinic acetylcholine receptors: pharmacological tools and endogenous modulators.

Authors:  Victor I Tsetlin
Journal:  Trends Pharmacol Sci       Date:  2014-12-17       Impact factor: 14.819

5.  Direct cloning of a target gene from a pool of homologous sequences: complete cDNA sequence of a weak neurotoxin from cobra Naja kaouthia.

Authors:  T L Oustitch; L E Peters; Yu N Utkin; V I Tsetlin
Journal:  IUBMB Life       Date:  2003-01       Impact factor: 3.885

6.  Naturally occurring disulfide-bound dimers of three-fingered toxins: a paradigm for biological activity diversification.

Authors:  Alexey V Osipov; Igor E Kasheverov; Yana V Makarova; Vladislav G Starkov; Olga V Vorontsova; Rustam Kh Ziganshin; Tatyana V Andreeva; Marina V Serebryakova; Audrey Benoit; Ronald C Hogg; Daniel Bertrand; Victor I Tsetlin; Yuri N Utkin
Journal:  J Biol Chem       Date:  2008-04-01       Impact factor: 5.157

7.  The complete primary structure of toxin CM-1b from Hemachatus haemachatus (Ringhals) snake venom.

Authors:  F J Joubert; N Taljaard
Journal:  Toxicon       Date:  1980       Impact factor: 3.033

8.  A Distinct Functional Site in Ω-Neurotoxins: Novel Antagonists of Nicotinic Acetylcholine Receptors from Snake Venom.

Authors:  Varuna Hassan-Puttaswamy; David J Adams; R Manjunatha Kini
Journal:  ACS Chem Biol       Date:  2015-10-15       Impact factor: 5.100

9.  Snake venom toxins. The amino acid sequences of two toxins (CM-2a and CM-3) from Naja haje annulifera (Egyptian cobra) venom.

Authors:  F J Joubert
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1977-03

10.  Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.

Authors:  E N Lyukmanova; M A Shulepko; Z O Shenkarev; M L Bychkov; A S Paramonov; A O Chugunov; D S Kulbatskii; M Arvaniti; Eva Dolejsi; T Schaer; A S Arseniev; R G Efremov; M S Thomsen; V Dolezal; D Bertrand; D A Dolgikh; M P Kirpichnikov
Journal:  Sci Rep       Date:  2016-08-03       Impact factor: 4.379
  10 in total

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