Literature DB >> 28864466

The Evolving Complexity of the Podocyte Cytoskeleton.

Christoph Schell1,2, Tobias B Huber3,4,5.   

Abstract

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
Copyright © 2017 by the American Society of Nephrology.

Entities:  

Keywords:  cytoskeleton; glomerular disease; nephrotic syndrome; podocyte

Mesh：

Year:  2017        PMID： 28864466      PMCID： PMC5661293          DOI： 10.1681/ASN.2017020143

Source DB:  PubMed          Journal:  J Am Soc Nephrol        ISSN： 1046-6673            Impact factor:   10.121


  114 in total

1.  Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.

Authors:  Young Sun Kang; Yingjian Li; Chunsun Dai; Lawrence P Kiss; Chuanyue Wu; Youhua Liu
Journal:  Kidney Int       Date:  2010-05-26       Impact factor: 10.612

2.  Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury.

Authors:  Jun Zou; Eishin Yaoita; Yusuke Watanabe; Yutaka Yoshida; Masaaki Nameta; Huiping Li; Zhenyun Qu; Tadashi Yamamoto
Journal:  Virchows Arch       Date:  2006-01-18       Impact factor: 4.064

3.  Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.

Authors:  Oleh Akchurin; Zhongfang Du; Nadira Ramkellawan; Vidhi Dalal; Seung Hyeok Han; James Pullman; Anne Müsch; Katalin Susztak; Kimberly J Reidy
Journal:  J Am Soc Nephrol       Date:  2016-05-16       Impact factor: 10.121

4.  Analysis of recessive CD2AP and ACTN4 mutations in steroid-resistant nephrotic syndrome.

Authors:  Geneviève Benoit; Eduardo Machuca; Fabien Nevo; Olivier Gribouval; David Lepage; Corinne Antignac
Journal:  Pediatr Nephrol       Date:  2009-12-03       Impact factor: 3.714

5.  ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.

Authors:  Heon Yung Gee; Pawaree Saisawat; Shazia Ashraf; Toby W Hurd; Virginia Vega-Warner; Humphrey Fang; Bodo B Beck; Olivier Gribouval; Weibin Zhou; Katrina A Diaz; Sivakumar Natarajan; Roger C Wiggins; Svjetlana Lovric; Gil Chernin; Dominik S Schoeb; Bugsu Ovunc; Yaacov Frishberg; Neveen A Soliman; Hanan M Fathy; Heike Goebel; Julia Hoefele; Lutz T Weber; Jeffrey W Innis; Christian Faul; Zhe Han; Joseph Washburn; Corinne Antignac; Shawn Levy; Edgar A Otto; Friedhelm Hildebrandt
Journal:  J Clin Invest       Date:  2013-07-08       Impact factor: 14.808

6.  Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.

Authors:  Keizo Kanasaki; Yoshiko Kanda; Kristin Palmsten; Harikrishna Tanjore; Soo Bong Lee; Valerie S Lebleu; Vincent H Gattone; Raghu Kalluri
Journal:  Dev Biol       Date:  2007-11-12       Impact factor: 3.582

7.  Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis.

Authors:  Elizabeth J Brown; Johannes S Schlöndorff; Daniel J Becker; Hiroyasu Tsukaguchi; Stephen J Tonna; Andrea L Uscinski; Henry N Higgs; Joel M Henderson; Martin R Pollak
Journal:  Nat Genet       Date:  2009-12-20       Impact factor: 38.330

8.  Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.

Authors:  Edward R Horton; Adam Byron; Janet A Askari; Daniel H J Ng; Angélique Millon-Frémillon; Joseph Robertson; Ewa J Koper; Nikki R Paul; Stacey Warwood; David Knight; Jonathan D Humphries; Martin J Humphries
Journal:  Nat Cell Biol       Date:  2015-10-19       Impact factor: 28.824

9.  Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

Authors:  Matthias J Hackl; James L Burford; Karie Villanueva; Lisa Lam; Katalin Suszták; Bernhard Schermer; Thomas Benzing; János Peti-Peterdi
Journal:  Nat Med       Date:  2013-11-24       Impact factor: 53.440

Review 10.  Role of Intermediate Filaments in Vesicular Traffic.

Authors:  Azzurra Margiotta; Cecilia Bucci
Journal:  Cells       Date:  2016-04-25       Impact factor: 6.600
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  45 in total

1.  Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis.

Authors:  Dawn J Caster; Erik A Korte; Min Tan; Michelle T Barati; Shweta Tandon; T Michael Creed; David J Salant; Jessica L Hata; Paul N Epstein; Hui Huang; David W Powell; Kenneth R McLeish
Journal:  Am J Physiol Renal Physiol       Date:  2018-05-23

2.  Signal regulatory protein α protects podocytes through promoting autophagic activity.

Authors:  Limin Li; Ying Liu; Shan Li; Rong Yang; Caihong Zeng; Weiwei Rong; Hongwei Liang; Mingchao Zhang; Xiaodong Zhu; Koby Kidder; Yuan Liu; Zhihong Liu; Ke Zen
Journal:  JCI Insight       Date:  2019-03-19

Review 3.  Mechanical challenges and cytoskeletal impairments in focal segmental glomerulosclerosis.

Authors:  Di Feng; Clark DuMontier; Martin R Pollak
Journal:  Am J Physiol Renal Physiol       Date:  2018-01-24

4.  Global phosphotyrosinylated protein profile of cell-matrix adhesion complexes of trabecular meshwork cells.

Authors:  Rupalatha Maddala; Ponugoti Vasantha Rao
Journal:  Am J Physiol Cell Physiol       Date:  2020-05-20       Impact factor: 4.249

5.  Triptolide potentiates the cytoskeleton-stabilizing activity of cyclosporine A in glomerular podocytes via a GSK3β dependent mechanism.

Authors:  Xianhui Liang; Bohan Chen; Pei Wang; Yan Ge; Deepak K Malhotra; Lance D Dworkin; Zhangsuo Liu; Rujun Gong
Journal:  Am J Transl Res       Date:  2020-03-15       Impact factor: 4.060

6.  Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.

Authors:  Di Feng; Mukesh Kumar; Jan Muntel; Susan B Gurley; Gabriel Birrane; Isaac E Stillman; Lai Ding; Minxian Wang; Saima Ahmed; Johannes Schlondorff; Seth L Alper; Tom Ferrante; Susan L Marquez; Carlos F Ng; Richard Novak; Donald E Ingber; Hanno Steen; Martin R Pollak
Journal:  J Am Soc Nephrol       Date:  2020-06-15       Impact factor: 10.121

7.  Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.

Authors:  Annika Möller-Kerutt; Juan E Rodriguez-Gatica; Karin Wacker; Rohan Bhatia; Jan-Peter Siebrasse; Nanda Boon; Veerle Van Marck; Peter Boor; Ulrich Kubitscheck; Jan Wijnholds; Hermann Pavenstädt; Thomas Weide
Journal:  J Am Soc Nephrol       Date:  2021-03-09       Impact factor: 10.121

Review 8.  Advances in the role and mechanism of zonulin pathway in kidney diseases.

Authors:  Jie Yu; Ying Shen; Nan Zhou
Journal:  Int Urol Nephrol       Date:  2021-01-11       Impact factor: 2.370

9.  SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

Authors:  Manuel Rogg; Jasmin I Maier; Robert Dotzauer; Nadine Artelt; Oliver Kretz; Martin Helmstädter; Ahmed Abed; Alena Sammarco; August Sigle; Dominik Sellung; Patrick Dinse; Karoline Reiche; Mako Yasuda-Yamahara; Martin L Biniossek; Gerd Walz; Martin Werner; Nicole Endlich; Oliver Schilling; Tobias B Huber; Christoph Schell
Journal:  J Am Soc Nephrol       Date:  2021-01-29       Impact factor: 10.121

10.  Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology.

Authors:  Wenjun Gao; Yedan Liu; Letao Fan; Baoying Zheng; Joshua R Jefferson; Shaoxun Wang; Huawei Zhang; Xing Fang; Bond V Nguyen; Tongyu Zhu; Richard J Roman; Fan Fan
Journal:  Am J Physiol Renal Physiol       Date:  2020-12-14
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