Nicholas Y Q Tan1, Yih-Chung Tham1, Victor Koh2, Duc Quang Nguyen1, Carol Y Cheung3, Tin Aung4, Tien Yin Wong4, Ching-Yu Cheng5. 1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. 2. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 3. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong. 4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore. 5. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, National University of Singapore, Singapore. Electronic address: chingyu.cheng@duke-nus.edu.sg.
Abstract
PURPOSE: To quantitatively determine how the reliability indices in standard automated perimetry (SAP) affect the global indices of visual field (VF) results in nonglaucomatous eyes. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 830 adults aged 40 to 80 years, without visual impairment, glaucoma, significant cataract, and major eye diseases, were selected from the population-based Singapore Chinese Eye Study (SCES). METHODS: Study participants underwent a comprehensive and standardized ocular examination and VF assessment using a Humphrey Field Analyzer II (Carl Zeiss Meditec, Inc., Dublin, CA). The effects of the test reliability, as indicated by the false-negative (FN), false-positive (FP), and fixation loss (FL) rates, on global indices, as indicated by the mean deviation (MD) and pattern standard deviation (PSD), were analyzed with multivariable regression models. MAIN OUTCOME MEASURES: The MD and PSD. RESULTS: A total of 1828 VF results from 1235 normal eyes of 830 study subjects were included in the analyses. The multivariable regression analyses adjusted for age, gender, best-corrected visual acuity, and test duration showed that at lower frequencies of false answers (<15%), FNs decreased the MD (β [change in decibels {dB} per 5% increment in false answers] = -0.71 dB; P < 0.001), whereas FPs increased the MD (β = 0.65 dB; P < 0.001). At higher frequencies (≥15%), the false answers influenced the MD to a greater extent, where the β for the associations with FN and FP rates was -1.15 and 1.26 dB, respectively (both P < 0.001). We also found that when FN rate was <15%, higher FN rate increased the PSD (β = 0.51 dB; P < 0.001), and the effect was slightly larger when FN rate was ≥15% (β = 0.71 dB; P < 0.001). The effect of FPs on PSD was observed only when FP rate was <15% (β = -0.22 dB; P < 0.001). The FL had no associations with the MD, and had minimal effects on the PSD. CONCLUSIONS: We quantified the effect of unreliable responses on the MD and PSD in SAP. Our study may allow clinicians to estimate how VF results are affected by varying degrees of unreliability, instead of relying on cutoff values for reliability indices.
PURPOSE: To quantitatively determine how the reliability indices in standard automated perimetry (SAP) affect the global indices of visual field (VF) results in nonglaucomatous eyes. DESIGN: Observational, cross-sectional study. PARTICIPANTS: A total of 830 adults aged 40 to 80 years, without visual impairment, glaucoma, significant cataract, and major eye diseases, were selected from the population-based Singapore Chinese Eye Study (SCES). METHODS: Study participants underwent a comprehensive and standardized ocular examination and VF assessment using a Humphrey Field Analyzer II (Carl Zeiss Meditec, Inc., Dublin, CA). The effects of the test reliability, as indicated by the false-negative (FN), false-positive (FP), and fixation loss (FL) rates, on global indices, as indicated by the mean deviation (MD) and pattern standard deviation (PSD), were analyzed with multivariable regression models. MAIN OUTCOME MEASURES: The MD and PSD. RESULTS: A total of 1828 VF results from 1235 normal eyes of 830 study subjects were included in the analyses. The multivariable regression analyses adjusted for age, gender, best-corrected visual acuity, and test duration showed that at lower frequencies of false answers (<15%), FNs decreased the MD (β [change in decibels {dB} per 5% increment in false answers] = -0.71 dB; P < 0.001), whereas FPs increased the MD (β = 0.65 dB; P < 0.001). At higher frequencies (≥15%), the false answers influenced the MD to a greater extent, where the β for the associations with FN and FP rates was -1.15 and 1.26 dB, respectively (both P < 0.001). We also found that when FN rate was <15%, higher FN rate increased the PSD (β = 0.51 dB; P < 0.001), and the effect was slightly larger when FN rate was ≥15% (β = 0.71 dB; P < 0.001). The effect of FPs on PSD was observed only when FP rate was <15% (β = -0.22 dB; P < 0.001). The FL had no associations with the MD, and had minimal effects on the PSD. CONCLUSIONS: We quantified the effect of unreliable responses on the MD and PSD in SAP. Our study may allow clinicians to estimate how VF results are affected by varying degrees of unreliability, instead of relying on cutoff values for reliability indices.
Authors: Swarup S Swaminathan; Matthew B Greenberg; Elizabeth A Vanner; Kara M Cavuoto; Sarah R Wellik; Ta Chen Chang Journal: J Ophthalmol Date: 2018-02-12 Impact factor: 1.909
Authors: Inas F Aboobakar; Jiangxia Wang; Balwantray C Chauhan; Michael V Boland; David S Friedman; Pradeep Y Ramulu; Jithin Yohannan Journal: Transl Vis Sci Technol Date: 2020-01-30 Impact factor: 3.283