Literature DB >> 28861320

CS1 (SLAMF7, CD319) is an effective immunotherapeutic target for multiple myeloma.

Joseph D Malaer1, Porunelloor A Mathew1.   

Abstract

CS1 (also known as CD319, CRACC and SLAMF7) was identified as an NK cell receptor regulating immune functions. It is also expressed on B cells, T cells, Dendritic cells, NK-T cells, and monocytes. CS1 is overexpressed in multiple myeloma and makes it a target for immunotherapy. A humanized anti-CS1 antibody, Elotuzumab or Empliciti has shown promising results in clinical studies. This review focuses on the biology of CS1 in NK and other hematopoietic cells and multiple myeloma. Anti-CS1 mAb can activate natural cytotoxicity of NK cells as well as enhance ADCC (antibody-dependent cell-mediated cytotoxicity) and thus makes an effective target for immunotherapy of MM.

Entities:  

Keywords:  CRACC; CS1; SLAMF7; antibody-based immunotherapy; elotuzumab; multiple myeloma

Year:  2017        PMID： 28861320      PMCID： PMC5574936     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  34 in total

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Authors:  Robert A Kyle; S Vincent Rajkumar
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Journal:  Nat Rev Immunol       Date:  2006-01       Impact factor: 53.106

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Journal:  Blood       Date:  2010-12-03       Impact factor: 22.113

8.  YY1 and a unique DNA repeat element regulates the transcription of mouse CS1 (CD319, SLAMF7) gene.

Authors:  Prachi Dongre; Stephen Mathew; Irina Akopova; Ignacy Gryczynski; Porunelloor Mathew
Journal:  Mol Immunol       Date:  2013-01-11       Impact factor: 4.407

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Authors:  Yu-Tzu Tai; Myles Dillon; Weihua Song; Merav Leiba; Xian-Feng Li; Peter Burger; Alfred I Lee; Klaus Podar; Teru Hideshima; Audie G Rice; Anne van Abbema; Lynne Jesaitis; Ingrid Caras; Debbie Law; Edie Weller; Wanling Xie; Paul Richardson; Nikhil C Munshi; Claire Mathiot; Hervé Avet-Loiseau; Daniel E H Afar; Kenneth C Anderson
Journal:  Blood       Date:  2007-09-28       Impact factor: 22.113

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Authors:  David Savitsky; Kathryn Calame
Journal:  J Exp Med       Date:  2006-09-05       Impact factor: 14.307
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  36 in total

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Review 4.  Molecular imaging for cancer immunotherapy.

Authors:  E A Lim; C G Drake; A Mintz
Journal:  Immunooncol Technol       Date:  2020-03-27

Review 5.  NK cell recognition of hematopoietic cells by SLAM-SAP families.

Authors:  Shasha Chen; Zhongjun Dong
Journal:  Cell Mol Immunol       Date:  2019-03-25       Impact factor: 11.530

Review 6.  Mechanisms of Action of the New Antibodies in Use in Multiple Myeloma.

Authors:  Alessandra Romano; Paola Storti; Valentina Marchica; Grazia Scandura; Laura Notarfranchi; Luisa Craviotto; Francesco Di Raimondo; Nicola Giuliani
Journal:  Front Oncol       Date:  2021-07-08       Impact factor: 6.244

7.  Meta-analysis of global and high throughput public gene array data for robust vascular gene expression discovery in chronic rhinosinusitis: Implications in controlled release.

Authors:  Nitish Khurana; Abigail Pulsipher; Hamidreza Ghandehari; Jeremiah A Alt
Journal:  J Control Release       Date:  2020-11-02       Impact factor: 9.776

8.  Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7.

Authors:  Christina Amatya; Melissa A Pegues; Norris Lam; Danielle Vanasse; Claudia Geldres; Stephanie Choi; Stephen M Hewitt; Steven A Feldman; James N Kochenderfer
Journal:  Mol Ther       Date:  2020-10-14       Impact factor: 11.454

Review 9.  CAR-engineered NK cells; a promising therapeutic option for treatment of hematological malignancies.

Authors:  Faroogh Marofi; Marwan Mahmood Saleh; Heshu Sulaiman Rahman; Wanich Suksatan; Moaed E Al-Gazally; Walid Kamal Abdelbasset; Lakshmi Thangavelu; Alexei Valerievich Yumashev; Ali Hassanzadeh; Mahboubeh Yazdanifar; Roza Motavalli; Yashwant Pathak; Adel Naimi; Behzad Baradaran; Marzieh Nikoo; Farhad Motavalli Khiavi
Journal:  Stem Cell Res Ther       Date:  2021-07-02       Impact factor: 6.832

10.  Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

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Luka Čičin-Šain; Mario Clerici; Federico S Colombo; Laura Cook; Anne Cooke; Andrea M Cooper; Alexandra J Corbett; Antonio Cosma; Lorenzo Cosmi; Pierre G Coulie; Ana Cumano; Ljiljana Cvetkovic; Van Duc Dang; Chantip Dang-Heine; Martin S Davey; Derek Davies; Sara De Biasi; Genny Del Zotto; Gelo Victoriano Dela Cruz; Michael Delacher; Silvia Della Bella; Paolo Dellabona; Günnur Deniz; Mark Dessing; James P Di Santo; Andreas Diefenbach; Francesco Dieli; Andreas Dolf; Thomas Dörner; Regine J Dress; Diana Dudziak; Michael Dustin; Charles-Antoine Dutertre; Friederike Ebner; Sidonia B G Eckle; Matthias Edinger; Pascale Eede; Götz R A Ehrhardt; Marcus Eich; Pablo Engel; Britta Engelhardt; Anna Erdei; Charlotte Esser; Bart Everts; Maximilien Evrard; Christine S Falk; Todd A Fehniger; Mar Felipo-Benavent; Helen Ferry; Markus Feuerer; Andrew Filby; Kata Filkor; Simon Fillatreau; Marie Follo; Irmgard Förster; John Foster; Gemma A Foulds; Britta Frehse; Paul S Frenette; Stefan Frischbutter; Wolfgang Fritzsche; 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