Ming-Chun Chen1, Bang-Gee Hsu2, Chung-Jen Lee3, Chiu-Fen Yang4, Ji-Hung Wang5. 1. Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 2. Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. 3. Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan. 4. Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. 5. School of Medicine, Tzu Chi University, Hualien, Taiwan; Division of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan. Electronic address: jihung-wang@tzuchi.com.tw.
Abstract
BACKGROUND: The adipocyte-fatty-acid-binding protein (A-FABP) has been implicated in arterial stiffness, metabolic syndrome (MetS), and cardiovascular disease. We aimed to determine the relationship among serum A-FABP concentration, cardiometabolic risk factors, and central arterial stiffness in a hypertensive population. METHODS: Fasting blood samples and baseline characteristics were obtained from 110 hypertensive patients. Serum A-FABP concentrations were determined by enzyme immunoassay kit. High arterial stiffness was defined as carotid-femoral pulse wave velocity values >10m/s via the SphygmoCor system. RESULTS: Patients with MetS and high arterial stiffness accounted for 67.3% and 42.7% of the study population, respectively. Serum A-FABP was positively associated with MetS and high arterial stiffness (P=0.006 and P<0.001, respectively). Multivariable stepwise linear regression analysis of the significant variables of arterial stiffness revealed that logarithmically transformed A-FABP (log-A-FABP, β=0.278, P=0.002) was positively correlated arterial stiffness in hypertensive patients. Subgroup analysis revealed that log-A-FABP (β=0.327, P=0.003), age (β=0229, P=0.032), and triglyceride (β=0.307, P=0.004) were significantly positively correlated with arterial stiffness in hypertensive patients with MetS. CONCLUSIONS: Elevated A-FABP concentration could be a predictor for MetS and arterial stiffness in hypertensive patients.
BACKGROUND: The adipocyte-fatty-acid-binding protein (A-FABP) has been implicated in arterial stiffness, metabolic syndrome (MetS), and cardiovascular disease. We aimed to determine the relationship among serum A-FABP concentration, cardiometabolic risk factors, and central arterial stiffness in a hypertensive population. METHODS: Fasting blood samples and baseline characteristics were obtained from 110 hypertensivepatients. Serum A-FABP concentrations were determined by enzyme immunoassay kit. High arterial stiffness was defined as carotid-femoral pulse wave velocity values >10m/s via the SphygmoCor system. RESULTS:Patients with MetS and high arterial stiffness accounted for 67.3% and 42.7% of the study population, respectively. Serum A-FABP was positively associated with MetS and high arterial stiffness (P=0.006 and P<0.001, respectively). Multivariable stepwise linear regression analysis of the significant variables of arterial stiffness revealed that logarithmically transformed A-FABP (log-A-FABP, β=0.278, P=0.002) was positively correlated arterial stiffness in hypertensivepatients. Subgroup analysis revealed that log-A-FABP (β=0.327, P=0.003), age (β=0229, P=0.032), and triglyceride (β=0.307, P=0.004) were significantly positively correlated with arterial stiffness in hypertensivepatients with MetS. CONCLUSIONS: Elevated A-FABP concentration could be a predictor for MetS and arterial stiffness in hypertensivepatients.
Authors: Boya Liao; Leiluo Geng; Fang Zhang; Lingling Shu; Ling Wei; Patrick K K Yeung; Karen S L Lam; Sookja K Chung; Junlei Chang; Paul M Vanhoutte; Aimin Xu; Kai Wang; Ruby L C Hoo Journal: Eur Heart J Date: 2020-09-01 Impact factor: 29.983