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Literature DB >> 2885998

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.

Abstract

Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P less than 0.01) 60%-80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (gamma-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.

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Year: 1987 PMID： 2885998 DOI： 10.1007/bf00693775

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

14 in total

1. The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus.

Authors: R Suzuki; T Yamaguchi; C L Li; I Klatzo
Journal: Acta Neuropathol Date: 1983 Impact factor: 17.088

2. Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport.

Authors: C E Ribak; J E Vaughn; K Saito
Journal: Brain Res Date: 1978-01-27 Impact factor: 3.252

3. A new model of bilateral hemispheric ischemia in the unanesthetized rat.

Authors: W A Pulsinelli; J B Brierley
Journal: Stroke Date: 1979 May-Jun Impact factor: 7.914

4. Delayed neuronal death in the gerbil hippocampus following ischemia.

Authors: T Kirino
Journal: Brain Res Date: 1982-05-06 Impact factor: 3.252

5. Developmental onset of long-term potentiation in area CA1 of the rat hippocampus.

Authors: K M Harris; T J Teyler
Journal: J Physiol Date: 1984-01 Impact factor: 5.182

6. Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations.

Authors: U Ito; M Spatz; J T Walker; I Klatzo
Journal: Acta Neuropathol Date: 1975-08-27 Impact factor: 17.088

7. Neuropeptides and astroglia in intracerebral hippocampal transplants: an immunohistochemical study in the rat.

Authors: J Zimmer; N Sunde
Journal: J Comp Neurol Date: 1984-08-10 Impact factor: 3.215

8. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique.

Authors: O P Ottersen; J Storm-Mathisen
Journal: J Comp Neurol Date: 1984-11-01 Impact factor: 3.215

9. Temporal profile of neuronal damage in a model of transient forebrain ischemia.

Authors: W A Pulsinelli; J B Brierley; F Plum
Journal: Ann Neurol Date: 1982-05 Impact factor: 10.422

10. Commissural projection to the dentate gyrus of the rat: evidence for feed-forward inhibition.

Authors: G Buzsàki; E Eidelberg
Journal: Brain Res Date: 1981-12-28 Impact factor: 3.252

42 in total

1. Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding.

Authors: J Deckert; M B Jorgensen
Journal: J Neural Transm Gen Sect Date: 1991

7. Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation.

Authors: Seiichiro Jinde; Veronika Zsiros; Zhihong Jiang; Kazuhito Nakao; James Pickel; Kenji Kohno; Juan E Belforte; Kazu Nakazawa
Journal: Neuron Date: 2012-12-20 Impact factor: 17.173

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.

1. The effects of 5-minute ischemia in Mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus.

2. Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport.

3. A new model of bilateral hemispheric ischemia in the unanesthetized rat.

4. Delayed neuronal death in the gerbil hippocampus following ischemia.

5. Developmental onset of long-term potentiation in area CA1 of the rat hippocampus.

6. Experimental cerebral ischemia in mongolian gerbils. I. Light microscopic observations.

7. Neuropeptides and astroglia in intracerebral hippocampal transplants: an immunohistochemical study in the rat.

8. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique.

9. Temporal profile of neuronal damage in a model of transient forebrain ischemia.

10. Commissural projection to the dentate gyrus of the rat: evidence for feed-forward inhibition.

1. Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding.

2. Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia.

3. GABA excitation in mouse hilar neuropeptide Y neurons.

Review 4. The CA3 "backprojection" to the dentate gyrus.

5. Neural grafting to ischemic lesions of the adult rat hippocampus.

6. Loss of hilar somatostatin neurons following tetanus toxin-induced seizures.

7. Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation.

8. Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices.

9. Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices.

10. Blockade of excitation reveals inhibition of dentate spiny hilar neurons recorded in rat hippocampal slices.