Literature DB >> 28859511

Why Are Innovative Drugs Failing in Phase III?

Stephen R Marder1, Thomas Laughren1, Steven J Romano1.   

Abstract

Keywords:  Clinical Drug Studies; Other Aspects Of Psychopharmacology

Mesh：

Substances：

Year:  2017        PMID： 28859511     DOI： 10.1176/appi.ajp.2017.17040426

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN： 0002-953X            Impact factor:   18.112


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  7 in total

Review 1.  Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia.

Authors:  Jason R Tregellas; Korey P Wylie
Journal:  Nicotine Tob Res       Date:  2019-02-18       Impact factor: 4.244

Review 2.  α7 nicotinic acetylcholine receptors as therapeutic targets in schizophrenia: Update on animal and clinical studies and strategies for the future.

Authors:  Alvin V Terry; Patrick M Callahan
Journal:  Neuropharmacology       Date:  2020-03-15       Impact factor: 5.250

3.  When All Else Fails, Listen to the Patient: A Viewpoint on the Use of Ecological Momentary Assessment in Clinical Trials.

Authors:  Aaron M Mofsen; Thomas L Rodebaugh; Ginger E Nicol; Colin A Depp; J Philip Miller; Eric J Lenze
Journal:  JMIR Ment Health       Date:  2019-04-21

4.  Number Of Clinical Trial Study Sites Impacts Observed Treatment Effect Size: An Analysis Of Randomized Controlled Trials Of Opioids For Chronic Pain.

Authors:  Diana S Meske; Ben J Vaughn; Ernest A Kopecky; Nathaniel Katz
Journal:  J Pain Res       Date:  2019-11-20       Impact factor: 3.133

5.  The Relative Effects of Prazosin on Individual PTSD Symptoms: Evidence for Pathophysiologically-Related Clustering.

Authors:  Rebecca C Hendrickson; Steven P Millard; Kathleen F Pagulayan; Elaine R Peskind; Murray A Raskind
Journal:  Chronic Stress (Thousand Oaks)       Date:  2021-02-09

6.  An Innovative Disease-Drug-Trial Framework to Guide Binge Eating Disorder Drug Development: A Case Study for Topiramate.

Authors:  Shamir N Kalaria; Susan L McElroy; Jogarao Gobburu; Mathangi Gopalakrishnan
Journal:  Clin Transl Sci       Date:  2019-09-09       Impact factor: 4.689

7.  John D. Loeser Award Lecture: Size does matter, but it isn't everything: the challenge of modest treatment effects in chronic pain clinical trials.

Authors:  Shannon M Smith; Maurizio Fava; Mark P Jensen; Omar B Mbowe; Michael P McDermott; Dennis C Turk; Robert H Dworkin
Journal:  Pain       Date:  2020-09       Impact factor: 7.926
  7 in total

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