Haisen Xia1, Guangya Zhang2, Xiangdong Du2, Yingyang Zhang2, Guangzhong Yin2, Jing Dai3, Man-Xi He3, Jair C Soares4, Xiaosi Li1, Xiang Yang Zhang4. 1. Hefei Fourth People's Hospital, Anhui Mental Health Center. 2. Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University. 3. Fourth People's Hospital of Chengdu, Chengdu Mental Health Center. 4. Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston.
Abstract
OBJECTIVE: Recent evidence suggests the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior. Because schizophrenia patients usually have high suicide rates and numerous studies have suggested that BDNF may contribute to the psychopathology of schizophrenia, we hypothesized that the functional polymorphism of BDNF (Val66Met) was associated with suicide attempts in patients with schizophrenia in a Chinese Han population. METHOD: This polymorphism was genotyped in 825 chronic schizophrenia patients with (n = 123) and without (n = 702) suicide attempts and 445 healthy controls without a history of suicide attempts using a case-control design. The schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale. RESULTS: There were no significant differences in BDNF Val66Met genotype and allele distributions between the patients and healthy controls. However, we found the Val allele (p = .023) and the Val/Val genotypes (p = .058) to be associated with a history of suicide attempts. Moreover, some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophrenia patients. CONCLUSIONS: The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophrenia patients. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
OBJECTIVE: Recent evidence suggests the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior. Because schizophreniapatients usually have high suicide rates and numerous studies have suggested that BDNF may contribute to the psychopathology of schizophrenia, we hypothesized that the functional polymorphism of BDNF (Val66Met) was associated with suicide attempts in patients with schizophrenia in a Chinese Han population. METHOD: This polymorphism was genotyped in 825 chronic schizophreniapatients with (n = 123) and without (n = 702) suicide attempts and 445 healthy controls without a history of suicide attempts using a case-control design. The schizophrenia symptoms were assessed by the Positive and Negative Syndrome Scale. RESULTS: There were no significant differences in BDNF Val66Met genotype and allele distributions between the patients and healthy controls. However, we found the Val allele (p = .023) and the Val/Val genotypes (p = .058) to be associated with a history of suicide attempts. Moreover, some clinical characteristics, including age and cigarettes smoked each day, interacted with the BDNF gene variant and appeared to play an important role in suicide attempts among schizophreniapatients. CONCLUSIONS: The BDNF Val66Met polymorphism itself and its interaction with some clinical variables may influence suicide attempts among schizophreniapatients. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
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