Floor Bennebroek Evertsz'1, Mirjam A G Sprangers1, Kate Sitnikova2, Pieter C F Stokkers3, Cyriel Y Ponsioen4, Joep F W M Bartelsman4, Ad A van Bodegraven5, Steven Fischer6, Annekatrien C T M Depla7, Rosalie C Mallant8, Robbert Sanderman9, Huibert Burger10, Claudi L H Bockting11. 1. Department of Medical Psychology. 2. Department of General Practice & Elderly Care Medicine, VU University Medical Center Amsterdam. 3. Department of Gastroenterology, Sint Lucas Andreas Hospital. 4. Department of Gastroenterology, Academic Medical Center, University of Amsterdam. 5. Department of Gastroenterology and Hepatology, VU University Medical Center Amsterdam. 6. Department of Medical Psychology, Slotervaart Hospital. 7. Department of Gastroenterology and Hepatology, Slotervaart Hospital. 8. Department of Gastroenterology and Hepatology, Flevo Hospital. 9. Department of Health Psychology, University Medical Center Groningen, University of Groningen. 10. Department of General Practice, University Medical Center Groningen, University of Groningen. 11. Department of Clinical and Health Psychology, University of Utrecht.
Abstract
OBJECTIVE:Inflammatory bowel disease (IBD) is characterized by a low level of quality of life (QoL) and a high prevalence of anxiety and depression, especially in patients with poor QoL. We examined the effect of IBD-specific cognitive-behavioral therapy (CBT) on QoL, anxiety, and depression in IBD patients with poor mental QoL. METHOD: This study is a parallel-group multicenter randomized controlled trial. One hundred eighteen IBD patients with a low level of QoL (score ≤23 on the mental health subscale of the Medical Outcomes Study Short Form 36 Health Survey [SF-36]) were included from 2 academic medical centers (Academic Medical Center Amsterdam, VU University Medical Centre Amsterdam) and 2 peripheral medical centers (Flevo Hospital, Slotervaart Hospital) in the Netherlands. Patients were randomized to an experimental group receiving CBT (n = 59) versus a wait-list control group (n = 59) receiving standard medical care for 3.5 months, followed by CBT. Both groups completed baseline and 3.5 months follow-up assessments. The primary outcome was a self-report questionnaire and disease-specific QoL (Inflammatory Bowel Disease Questionnaire [IBDQ]). Secondary outcomes were depression (Hospital Anxiety and Depression Scale-Depression Subscale [HADS-D], Center for Epidemiologic Studies Depression Scale [CES-D]), anxiety (HADS-Anxiety Subscale [HADS-A]) and generic QoL (SF-36). RESULTS: Data were analyzed both on intention to treat as well as on per protocol analysis (completed ≥5 sessions). CBT had a positive effect on disease-specific-QoL (Cohen's d = .64 for IBDQ total score), depression (Cohen's d = .48 for HADS-D and .78 for CES-D), anxiety (Cohen's d = .58 for HADS-A), and generic QoL (Cohen's d = 1.08 for Mental Component Summary of the SF-36; all ps < .01). CONCLUSIONS: IBD-specific CBT is effective in improving QoL and in decreasing anxiety and depression in IBD patients with poor QoL. Clinicians should incorporate screening on poor mental QoL and consider offering CBT. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
RCT Entities:
OBJECTIVE:Inflammatory bowel disease (IBD) is characterized by a low level of quality of life (QoL) and a high prevalence of anxiety and depression, especially in patients with poor QoL. We examined the effect of IBD-specific cognitive-behavioral therapy (CBT) on QoL, anxiety, and depression in IBDpatients with poor mental QoL. METHOD: This study is a parallel-group multicenter randomized controlled trial. One hundred eighteen IBDpatients with a low level of QoL (score ≤23 on the mental health subscale of the Medical Outcomes Study Short Form 36 Health Survey [SF-36]) were included from 2 academic medical centers (Academic Medical Center Amsterdam, VU University Medical Centre Amsterdam) and 2 peripheral medical centers (Flevo Hospital, Slotervaart Hospital) in the Netherlands. Patients were randomized to an experimental group receiving CBT (n = 59) versus a wait-list control group (n = 59) receiving standard medical care for 3.5 months, followed by CBT. Both groups completed baseline and 3.5 months follow-up assessments. The primary outcome was a self-report questionnaire and disease-specific QoL (Inflammatory Bowel Disease Questionnaire [IBDQ]). Secondary outcomes were depression (Hospital Anxiety and Depression Scale-Depression Subscale [HADS-D], Center for Epidemiologic Studies Depression Scale [CES-D]), anxiety (HADS-Anxiety Subscale [HADS-A]) and generic QoL (SF-36). RESULTS: Data were analyzed both on intention to treat as well as on per protocol analysis (completed ≥5 sessions). CBT had a positive effect on disease-specific-QoL (Cohen's d = .64 for IBDQ total score), depression (Cohen's d = .48 for HADS-D and .78 for CES-D), anxiety (Cohen's d = .58 for HADS-A), and generic QoL (Cohen's d = 1.08 for Mental Component Summary of the SF-36; all ps < .01). CONCLUSIONS:IBD-specific CBT is effective in improving QoL and in decreasing anxiety and depression in IBDpatients with poor QoL. Clinicians should incorporate screening on poor mental QoL and consider offering CBT. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
Authors: Luuk Stapersma; Gertrude van den Brink; Jan van der Ende; Eva M Szigethy; Ruud Beukers; Thea A Korpershoek; Sabine D M Theuns-Valks; Manon H J Hillegers; Johanna C Escher; Elisabeth M W J Utens Journal: J Pediatr Psychol Date: 2018-10-01
Authors: Luuk Stapersma; Gertrude van den Brink; Jan van der Ende; Eva M Szigethy; Michael Groeneweg; Frederieke H de Bruijne; Manon H J Hillegers; Johanna C Escher; Elisabeth M W J Utens Journal: J Clin Psychol Med Settings Date: 2020-09
Authors: Gaurav Syal; Mariastella Serrano; Animesh Jain; Benjamin L Cohen; Florian Rieder; Christian Stone; Bincy Abraham; David Hudesman; Lisa Malter; Robert McCabe; Stefan Holubar; Anita Afzali; Adam S Cheifetz; Jill K J Gaidos; Alan C Moss Journal: Inflamm Bowel Dis Date: 2021-10-18 Impact factor: 5.325