Literature DB >> 28856762

Pregbalin induced recurrent syncopal attacks with prolong QT interval.

Adem Adar1, Fahri Cakan2, Orhan Önalan2.   

Abstract

Long QT syndrome may lead to fatal dysrhythmia. Prolongation of QT interval due to pregabalin has been shown in rats and no data is available in humans. We report a 80-year-old female patient using pregabalin. She was presented to emergency room with syncope attacks. Her admission electrocardiography demonstrated prolonged QT interval. After excluding the possible causes of the long QT syndrome, we attributed prolonged QT interval to pregabalin therapy. After discontinuation of pregabalin QT interval returned to normal range and patient experienced no further syncope attacks. It is first time for documentation of prolonged QT due to pregabalin in humans.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  long QT syndrome; pregabalin; syncope

Mesh：

Substances：

Year:  2017        PMID： 28856762      PMCID： PMC6931633          DOI： 10.1111/anec.12489

Source DB:  PubMed          Journal:  Ann Noninvasive Electrocardiol        ISSN： 1082-720X            Impact factor:   1.468


  9 in total

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Journal:  JAMA       Date:  2003 Apr 23-30       Impact factor: 56.272

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Journal:  Clin Cardiol       Date:  2011-09-01       Impact factor: 2.882

4.  Complete atrioventricular block due to overdose of pregabalin.

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Journal:  Am J Emerg Med       Date:  2012-05-23       Impact factor: 2.469

Review 5.  Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors.

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Review 6.  Efficacy and safety of pregabalin in generalised anxiety disorder: A critical review of the literature.

Authors:  David S Baldwin; Johan A den Boer; Gavin Lyndon; Birol Emir; Edward Schweizer; Hannah Haswell
Journal:  J Psychopharmacol       Date:  2015-08-10       Impact factor: 4.153

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Journal:  J Cardiovasc Med (Hagerstown)       Date:  2008-09       Impact factor: 2.160

8.  Effects of therapeutic doses of Pregabalin on QTc interval in conscious rabbits.

Authors:  R Alp; M Citil; M Uzun; S Alp; B Topcu; E Uzlu; H M Erdogan
Journal:  Eur Rev Med Pharmacol Sci       Date:  2008 Jul-Aug       Impact factor: 3.507

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Authors:  Santosh Bhusal; Sherilyn Diomampo; Marina N Magrey
Journal:  Drug Healthc Patient Saf       Date:  2016-02-17
  9 in total
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  1 in total

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