Literature DB >> 28855734

A caspase-independent way to kill cancer cells.

Brent E Fitzwalter1, Andrew Thorburn1.   

Abstract

Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.

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Year:  2017        PMID： 28855734     DOI： 10.1038/ncb3604

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

Review 1.  The hallmarks of cancer.

Authors:  D Hanahan; R A Weinberg
Journal:  Cell       Date:  2000-01-07       Impact factor: 41.582

2.  Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes.

Authors:  F Basit; S Cristofanon; S Fulda
Journal:  Cell Death Differ       Date:  2013-06-07       Impact factor: 15.828

Review 3.  Mitochondria: gatekeepers of response to chemotherapy.

Authors:  Kristopher A Sarosiek; Triona Ni Chonghaile; Anthony Letai
Journal:  Trends Cell Biol       Date:  2013-09-21       Impact factor: 20.808

4.  A BH3 Mimetic for Killing Cancer Cells.

Authors:  Douglas R Green
Journal:  Cell       Date:  2016-06-16       Impact factor: 41.582

5.  RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.

Authors:  Nader Yatim; Hélène Jusforgues-Saklani; Susana Orozco; Oliver Schulz; Rosa Barreira da Silva; Caetano Reis e Sousa; Douglas R Green; Andrew Oberst; Matthew L Albert
Journal:  Science       Date:  2015-09-24       Impact factor: 47.728

Review 6.  Immunogenic and tolerogenic cell death.

Authors:  Douglas R Green; Thomas Ferguson; Laurence Zitvogel; Guido Kroemer
Journal:  Nat Rev Immunol       Date:  2009-05       Impact factor: 53.106

7.  Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics.

Authors:  Gi-Bang Koo; Michael J Morgan; Da-Gyum Lee; Woo-Jung Kim; Jung-Ho Yoon; Ja Seung Koo; Seung Il Kim; Soo Jung Kim; Mi Kwon Son; Soon Sun Hong; Jean M Mulcahy Levy; Daniel A Pollyea; Craig T Jordan; Pearlly Yan; David Frankhouser; Deedra Nicolet; Kati Maharry; Guido Marcucci; Kyeong Sook Choi; Hyeseong Cho; Andrew Thorburn; You-Sun Kim
Journal:  Cell Res       Date:  2015-05-08       Impact factor: 25.617

8.  The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.

Authors:  Megan L Goodall; Brent E Fitzwalter; Shadi Zahedi; Min Wu; Diego Rodriguez; Jean M Mulcahy-Levy; Douglas R Green; Michael Morgan; Scott D Cramer; Andrew Thorburn
Journal:  Dev Cell       Date:  2016-05-23       Impact factor: 12.270

9.  Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.

Authors:  Qian Huang; Fang Li; Xinjian Liu; Wenrong Li; Wei Shi; Fei-Fei Liu; Brian O'Sullivan; Zhimin He; Yuanlin Peng; Aik-Choon Tan; Ling Zhou; Jingping Shen; Gangwen Han; Xiao-Jing Wang; Jackie Thorburn; Andrew Thorburn; Antonio Jimeno; David Raben; Joel S Bedford; Chuan-Yuan Li
Journal:  Nat Med       Date:  2011-07-03       Impact factor: 53.440

Review 10.  Therapeutic Targeting of Autophagy.

Authors:  Christina G Towers; Andrew Thorburn
Journal:  EBioMedicine       Date:  2016-10-23       Impact factor: 8.143
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  3 in total

1.  Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

Authors:  Florian Adanitsch; Jianjin Shi; Feng Shao; Rudi Beyaert; Holger Heine; Alla Zamyatina
Journal:  Chem Sci       Date:  2018-03-15       Impact factor: 9.825

2.  Extracts of Knoxia roxburghii (Spreng.) M. A. Rau Induce Apoptosis in Human MCF-7 Breast Cancer Cells via Mitochondrial Pathways.

Authors:  Xiao-Jiao Chen; Xin-Ying Pu; Xue-Mei Pu; Xue Li; Zhi-Bo Liu; Mi-Jia Mei; Xin-Ge Wang; Fan Zhang; Bin Qiu; Jie Yu
Journal:  Molecules       Date:  2022-09-29       Impact factor: 4.927

3.  Caspase-mediated cleavage of the centrosomal proteins during apoptosis.

Authors:  Mi Young Seo; Kunsoo Rhee
Journal:  Cell Death Dis       Date:  2018-05-01       Impact factor: 8.469
  3 in total

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