Kristina Bertl1, Arlinda Parllaku2, Nikolaos Pandis3, Kåre Buhlin4, Björn Klinge5, Andreas Stavropoulos6. 1. Department of Periodontology, Faculty of Odontology, University of Malmö, Sweden; Division of Oral Surgery, School of Dentistry, Medical University of Vienna, Austria. 2. Private Practice, Tirana, Albania; Postgraduate Course Periodontology, Medical University of Vienna. 3. School of Dental Medicine, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland. 4. Department of Dental Medicine, Division of Periodontology, Karolinska Institute, Huddinge, Sweden. 5. Department of Periodontology, Faculty of Odontology, University of Malmö, Sweden. 6. Department of Periodontology, Faculty of Odontology, University of Malmö, Sweden. Electronic address: andreas.stavropoulos@mah.se.
Abstract
OBJECTIVES: To evaluate the effect of local and/or systemic statin use as an adjunct to non-surgical and/or surgical periodontal therapy. DATA: Literature search according to PRISMA guidelines with the following eligibility criteria: (a) English or German language; (b) interventional studies; (c) statins as monotherapy or as an adjunct to non-surgical and/or surgical treatment of periodontitis; (d) clinical and/or radiographic treatment effect size of statin intake reported. SOURCES: Medline (PubMed), Embase (Ovid), CENTRAL (Ovid). STUDY SELECTION: Thirteen clinical studies regarding local application and 2 with systemic administration of statins as an adjunct to non-surgical treatment (SRP) and 4 studies regarding intrasurgical statin application with a maximum follow-up of 9 months could be included; simvastatin, atorvastatin, and rosuvastatin were used. Local but not systemic statin application as an adjunct to SRP yielded significantly larger probing pocket depth (PD), radiographic defect depth (RDD), and bleeding index reduction, and larger clinical attachment level gain, and less residual PD and RDD (p≤0.016); rosuvastatin appeared as the most efficacious. Three of 4 studies reported a significant positive effect of intrasurgical statin application. No adverse events were reported after statin use. The vast majority of the included studies were from the same research group. CONCLUSIONS: Significant additional clinical and radiographic improvements are obtained after local, but not systemic, statin use as an adjunct to SRP in deep pockets associated with intrabony defects and seemingly with furcation defects; intrasurgical statin application seems similarly beneficial. Confirmation of these results, and especially of the effect size, from other research groups is warranted.
OBJECTIVES: To evaluate the effect of local and/or systemic statin use as an adjunct to non-surgical and/or surgical periodontal therapy. DATA: Literature search according to PRISMA guidelines with the following eligibility criteria: (a) English or German language; (b) interventional studies; (c) statins as monotherapy or as an adjunct to non-surgical and/or surgical treatment of periodontitis; (d) clinical and/or radiographic treatment effect size of statin intake reported. SOURCES: Medline (PubMed), Embase (Ovid), CENTRAL (Ovid). STUDY SELECTION: Thirteen clinical studies regarding local application and 2 with systemic administration of statins as an adjunct to non-surgical treatment (SRP) and 4 studies regarding intrasurgical statin application with a maximum follow-up of 9 months could be included; simvastatin, atorvastatin, and rosuvastatin were used. Local but not systemic statin application as an adjunct to SRP yielded significantly larger probing pocket depth (PD), radiographic defect depth (RDD), and bleeding index reduction, and larger clinical attachment level gain, and less residual PD and RDD (p≤0.016); rosuvastatin appeared as the most efficacious. Three of 4 studies reported a significant positive effect of intrasurgical statin application. No adverse events were reported after statin use. The vast majority of the included studies were from the same research group. CONCLUSIONS: Significant additional clinical and radiographic improvements are obtained after local, but not systemic, statin use as an adjunct to SRP in deep pockets associated with intrabony defects and seemingly with furcation defects; intrasurgical statin application seems similarly beneficial. Confirmation of these results, and especially of the effect size, from other research groups is warranted.
Authors: Mariano Sanz; Alvaro Marco Del Castillo; Søren Jepsen; Jose R Gonzalez-Juanatey; Francesco D'Aiuto; Philippe Bouchard; Iain Chapple; Thomas Dietrich; Israel Gotsman; Filippo Graziani; David Herrera; Bruno Loos; Phoebus Madianos; Jean-Baptiste Michel; Pablo Perel; Burkert Pieske; Lior Shapira; Michael Shechter; Maurizio Tonetti; Charalambos Vlachopoulos; Gernot Wimmer Journal: J Clin Periodontol Date: 2020-02-03 Impact factor: 8.728
Authors: Ewa Pająk-Łysek; Maciej Polak; Grzegorz Kopeć; Mateusz Podolec; Moïse Desvarieux; Andrzej Pająk; Joanna Zarzecka Journal: Int J Environ Res Public Health Date: 2021-01-18 Impact factor: 3.390
Authors: M Sanz; A Marco Del Castillo; S Jepsen; J R Gonzalez-Juanatey; F D'Aiuto; P Bouchard; I Chapple; T Dietrich; I Gotsman; F Graziani; D Herrera; B Loos; P Madianos; J B Michel; P Perel; B Pieske; L Shapira; M Shechter; M Tonetti; C Vlachopoulos; G Wimmer Journal: Glob Heart Date: 2020-02-03