| Literature DB >> 28855134 |
Shangshang Li1, Hui Liu1, Wenshuai Wang1, Xiuxiu Wang1, Chen Zhang1, Jianjun Zhang1, Huijuan Jing1, Zhenzhen Ren1, Zheng Gao1, Xinling Song1, Le Jia2.
Abstract
This study was designed to investigate the antioxidant and anti-aging effects of D-galatose-induced (D-gal-induced) aging mice as well as monosaccharide compositions of acidic-extractable polysaccharides (AcAPS) and its major purified fractions (AcAPS-1, AcAPS-2 and AcAPS-3) from the fruiting body of Agaricus bisporus. In the in vitro assays, AcAPS-2 showed superior scavenging activities on hydroxyl (82.98±4.67%) and DPPH (64.47±4.05%) radicals at the concentration of 1.0mg/mL than AcAPS and other polysaccharides fractions. For in vivo anti-aging analysis, AcAPS-2 showed superior effects on hepatic and nephric protection by improving serum enzyme activities, biochemical levels, lipid contents and antioxidant status, respectively. The monosaccharide analysis showed that rhamnose (Rha) and glucose (Glu) may play vital roles in maintaining the antioxidant and anti-aging activities. The results suggested that both AcAPS and its purified fractions might be suitable for functional foods and natural drugs in preventing the acute aging-associated diseases.Entities:
Keywords: Acidic-extractable polysaccharides; Antioxidant and anti-aging effects; Purification
Mesh：
Substances：
Year: 2017 PMID： 28855134 DOI： 10.1016/j.ijbiomac.2017.08.135
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953