Emanuela Esposito1, Rosa Di Micco2, Oreste D Gentilini3. 1. Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via Pansini 5, Building 7D, 80131, Naples, Italy. Electronic address: emanuelaexpo@hotmail.it. 2. Department of Clinical Medicine and Surgery, Breast Unit, University of Naples Federico II, Via Pansini 5, Building 7D, 80131, Naples, Italy; Breast Surgery and Breast Unit, San Raffaele Scientific and University Hospital, Via Olgettina, 60, 20132, Milan, Italy. Electronic address: rosadimicco@alice.it. 3. Breast Surgery and Breast Unit, San Raffaele Scientific and University Hospital, Via Olgettina, 60, 20132, Milan, Italy. Electronic address: gentilini.oreste@hsr.it.
Abstract
INTRODUCTION: Sentinel Lymph Node Biopsy (SLNB) is regarded as the standard procedure for nodal staging in patients with early breast cancer. In the last decade several randomized trials have been evaluating its role and indications. MATERIALS AND METHODS: This article reviews recent and ongoing randomized trials on SLNB. RESULTS: Four randomized controlled trials have recently shown evidence that SLNB either alone or followed by radiation therapy is effective for the management in patients with low axillary tumor burden in early breast cancer. Nine randomized controlled trials on SLNB are ongoing: four assessing its role in case of positive sentinel node, three evaluating whether SLNB itself can be omitted when the preoperative nodal imaging is negative, two are studying SLNB in the neoadjuvant setting. DISCUSSION AND CONCLUSION: SLNB either alone or with axillary radiotherapy has been shown to be non-inferior to complete axillary dissection in terms of local recurrence, disease-free survival and overall survival in early breast cancer with minimally metastatic axilla. So far, results from ongoing trials are going to confirm the appropriate treatment in patients with limited axillary nodal involvement, the role and the timing of SLNB within the neoadjuvant setting and to define whether surgery can be avoided in the axilla in early stage breast cancer patients with negative preoperative imaging.
INTRODUCTION: Sentinel Lymph Node Biopsy (SLNB) is regarded as the standard procedure for nodal staging in patients with early breast cancer. In the last decade several randomized trials have been evaluating its role and indications. MATERIALS AND METHODS: This article reviews recent and ongoing randomized trials on SLNB. RESULTS: Four randomized controlled trials have recently shown evidence that SLNB either alone or followed by radiation therapy is effective for the management in patients with low axillary tumor burden in early breast cancer. Nine randomized controlled trials on SLNB are ongoing: four assessing its role in case of positive sentinel node, three evaluating whether SLNB itself can be omitted when the preoperative nodal imaging is negative, two are studying SLNB in the neoadjuvant setting. DISCUSSION AND CONCLUSION: SLNB either alone or with axillary radiotherapy has been shown to be non-inferior to complete axillary dissection in terms of local recurrence, disease-free survival and overall survival in early breast cancer with minimally metastatic axilla. So far, results from ongoing trials are going to confirm the appropriate treatment in patients with limited axillary nodal involvement, the role and the timing of SLNB within the neoadjuvant setting and to define whether surgery can be avoided in the axilla in early stage breast cancerpatients with negative preoperative imaging.
Authors: Jana de Boniface; Marcus Schmidt; Jutta Engel; Marjolein L Smidt; Birgitte Vrou Offersen; Toralf Reimer Journal: Breast Care (Basel) Date: 2018-09-05 Impact factor: 2.860
Authors: Juan C Vázquez; Antonio Piñero; Francisco J de Castro; Ana Lluch; Miguel Martín; Agustí Barnadas; Emilio Alba; Álvaro Rodríguez-Lescure; Federico Rojo; Julia Giménez; Ivan Solá; Maria J Quintana; Xavier Bonfill; Gerard Urrutia; Pedro Sánchez-Rovira Journal: Clin Transl Oncol Date: 2022-09-25 Impact factor: 3.340
Authors: Kwang Hyun Yoon; Seho Park; Jee Ye Kim; Hyung Seok Park; Seung Il Kim; Young Up Cho; Byeong-Woo Park Journal: Ann Surg Treat Res Date: 2019-07-29 Impact factor: 1.859