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Literature DB >> 28854182

Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer.

Abstract

ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

Entities: Disease Gene

Mesh：

Substances：

Year: 2017 PMID： 28854182 DOI： 10.1038/ng.3944

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

15 in total

1. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.

Authors: Qianben Wang; Wei Li; X Shirley Liu; Jason S Carroll; Olli A Jänne; Erika Krasnickas Keeton; Arul M Chinnaiyan; Kenneth J Pienta; Myles Brown
Journal: Mol Cell Date: 2007-08-03 Impact factor: 17.970

2. What are super-enhancers?

Authors: Sebastian Pott; Jason D Lieb
Journal: Nat Genet Date: 2015-01 Impact factor: 38.330

3. TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

Authors: Ken J Kron; Alexander Murison; Stanley Zhou; Vincent Huang; Takafumi N Yamaguchi; Yu-Jia Shiah; Michael Fraser; Theodorus van der Kwast; Paul C Boutros; Robert G Bristow; Mathieu Lupien
Journal: Nat Genet Date: 2017-08-07 Impact factor: 38.330

4. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.

Authors: J Li; C Yen; D Liaw; K Podsypanina; S Bose; S I Wang; J Puc; C Miliaresis; L Rodgers; R McCombie; S H Bigner; B C Giovanella; M Ittmann; B Tycko; H Hibshoosh; M H Wigler; R Parsons
Journal: Science Date: 1997-03-28 Impact factor: 47.728

Review 5. The oncogene ERG: a key factor in prostate cancer.

Authors: P Adamo; M R Ladomery
Journal: Oncogene Date: 2015-04-27 Impact factor: 9.867

6. Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Authors: Warren A Whyte; David A Orlando; Denes Hnisz; Brian J Abraham; Charles Y Lin; Michael H Kagey; Peter B Rahl; Tong Ihn Lee; Richard A Young
Journal: Cell Date: 2013-04-11 Impact factor: 41.582

7. Role of the TMPRSS2-ERG gene fusion in prostate cancer.

Authors: Scott A Tomlins; Bharathi Laxman; Sooryanarayana Varambally; Xuhong Cao; Jindan Yu; Beth E Helgeson; Qi Cao; John R Prensner; Mark A Rubin; Rajal B Shah; Rohit Mehra; Arul M Chinnaiyan
Journal: Neoplasia Date: 2008-02 Impact factor: 5.715

8. The Molecular Taxonomy of Primary Prostate Cancer.

Authors:
Journal: Cell Date: 2015-11-05 Impact factor: 41.582

9. The genomic complexity of primary human prostate cancer.

Authors: Michael F Berger; Michael S Lawrence; Francesca Demichelis; Yotam Drier; Kristian Cibulskis; Andrey Y Sivachenko; Andrea Sboner; Raquel Esgueva; Dorothee Pflueger; Carrie Sougnez; Robert Onofrio; Scott L Carter; Kyung Park; Lukas Habegger; Lauren Ambrogio; Timothy Fennell; Melissa Parkin; Gordon Saksena; Douglas Voet; Alex H Ramos; Trevor J Pugh; Jane Wilkinson; Sheila Fisher; Wendy Winckler; Scott Mahan; Kristin Ardlie; Jennifer Baldwin; Jonathan W Simons; Naoki Kitabayashi; Theresa Y MacDonald; Philip W Kantoff; Lynda Chin; Stacey B Gabriel; Mark B Gerstein; Todd R Golub; Matthew Meyerson; Ashutosh Tewari; Eric S Lander; Gad Getz; Mark A Rubin; Levi A Garraway
Journal: Nature Date: 2011-02-10 Impact factor: 49.962

Expanding the effects of ERG on chromatin landscapes and dysregulated transcription in prostate cancer.

1. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.

2. What are super-enhancers?

3. TMPRSS2-ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer.

4. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.

Review 5. The oncogene ERG: a key factor in prostate cancer.

6. Master transcription factors and mediator establish super-enhancers at key cell identity genes.

7. Role of the TMPRSS2-ERG gene fusion in prostate cancer.

8. The Molecular Taxonomy of Primary Prostate Cancer.

9. The genomic complexity of primary human prostate cancer.

Review 10. 3D genome organization in health and disease: emerging opportunities in cancer translational medicine.

Review 1. Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain.

Review 2. Super-enhancer function and its application in cancer targeted therapy.

Review 3. Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms.

Review 4. Super-enhancer function and its application in cancer targeted therapy.