Literature DB >> 28853876

Biomimetic Synthesis of Lankacidin Antibiotics.

Kuan Zheng1,2, Defeng Shen1,2, Ran Hong1.   

Abstract

We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.

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Year:  2017        PMID： 28853876     DOI： 10.1021/jacs.7b08500

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  3 in total

1.  Synthesis, Structural Reassignment, and Antibacterial Evaluation of 2,18-Seco-Lankacidinol B.

Authors:  Yanmin Yao; Lingchao Cai; Ian B Seiple
Journal:  Angew Chem Int Ed Engl       Date:  2018-09-11       Impact factor: 15.336

2.  Modular Chemical Synthesis of Streptogramin and Lankacidin Antibiotics.

Authors:  Lingchao Cai; Ian B Seiple; Qi Li
Journal:  Acc Chem Res       Date:  2021-04-01       Impact factor: 22.384

3.  Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt.

Authors:  Mohamed Sebak; Amal E Saafan; Sameh AbdelGhani; Walid Bakeer; Ahmed O El-Gendy; Laia Castaño Espriu; Katherine Duncan; RuAngelie Edrada-Ebel
Journal:  PLoS One       Date:  2019-12-30       Impact factor: 3.240
  3 in total

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