Literature DB >> 28853739

Structural biology: Full monty of family B GPCRs.

Thue W Schwartz1, Thomas M Frimurer2.   

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Year:  2017        PMID： 28853739     DOI： 10.1038/nchembio.2438

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  10 in total

Review 1.  Glucagon and GLP-1 receptors: lessons from chimeric ligands and receptors.

Authors:  S A Hjorth; T W Schwartz
Journal:  Acta Physiol Scand       Date:  1996-07

2.  GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release.

Authors:  A H Sparre-Ulrich; M N Gabe; L S Gasbjerg; C B Christiansen; B Svendsen; B Hartmann; J J Holst; M M Rosenkilde
Journal:  Biochem Pharmacol       Date:  2017-02-22       Impact factor: 5.858

3.  Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.

Authors:  Gaojie Song; Dehua Yang; Yuxia Wang; Chris de Graaf; Qingtong Zhou; Shanshan Jiang; Kaiwen Liu; Xiaoqing Cai; Antao Dai; Guangyao Lin; Dongsheng Liu; Fan Wu; Yiran Wu; Suwen Zhao; Li Ye; Gye Won Han; Jesper Lau; Beili Wu; Michael A Hanson; Zhi-Jie Liu; Ming-Wei Wang; Raymond C Stevens
Journal:  Nature       Date:  2017-05-17       Impact factor: 49.962

4.  Crystal structure of the GLP-1 receptor bound to a peptide agonist.

Authors:  Ali Jazayeri; Mathieu Rappas; Alastair J H Brown; James Kean; James C Errey; Nathan J Robertson; Cédric Fiez-Vandal; Stephen P Andrews; Miles Congreve; Andrea Bortolato; Jonathan S Mason; Asma H Baig; Iryna Teobald; Andrew S Doré; Malcolm Weir; Robert M Cooke; Fiona H Marshall
Journal:  Nature       Date:  2017-05-31       Impact factor: 49.962

5.  A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

Authors:  Whitney M Nolte; Jean-Philippe Fortin; Benjamin D Stevens; Gary E Aspnes; David A Griffith; Lise R Hoth; Roger B Ruggeri; Alan M Mathiowetz; Chris Limberakis; David Hepworth; Philip A Carpino
Journal:  Nat Chem Biol       Date:  2014-07-06       Impact factor: 15.040

6.  Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors:  Søren G F Rasmussen; Brian T DeVree; Yaozhong Zou; Andrew C Kruse; Ka Young Chung; Tong Sun Kobilka; Foon Sun Thian; Pil Seok Chae; Els Pardon; Diane Calinski; Jesper M Mathiesen; Syed T A Shah; Joseph A Lyons; Martin Caffrey; Samuel H Gellman; Jan Steyaert; Georgios Skiniotis; William I Weis; Roger K Sunahara; Brian K Kobilka
Journal:  Nature       Date:  2011-07-19       Impact factor: 49.962

7.  Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

Authors:  Yan Zhang; Bingfa Sun; Dan Feng; Hongli Hu; Matthew Chu; Qianhui Qu; Jeffrey T Tarrasch; Shane Li; Tong Sun Kobilka; Brian K Kobilka; Georgios Skiniotis
Journal:  Nature       Date:  2017-05-24       Impact factor: 49.962

8.  Extra-helical binding site of a glucagon receptor antagonist.

Authors:  Ali Jazayeri; Andrew S Doré; Daniel Lamb; Harini Krishnamurthy; Stacey M Southall; Asma H Baig; Andrea Bortolato; Markus Koglin; Nathan J Robertson; James C Errey; Stephen P Andrews; Iryna Teobald; Alastair J H Brown; Robert M Cooke; Malcolm Weir; Fiona H Marshall
Journal:  Nature       Date:  2016-04-25       Impact factor: 69.504

9.  Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Authors:  Yi-Lynn Liang; Maryam Khoshouei; Mazdak Radjainia; Yan Zhang; Alisa Glukhova; Jeffrey Tarrasch; David M Thal; Sebastian G B Furness; George Christopoulos; Thomas Coudrat; Radostin Danev; Wolfgang Baumeister; Laurence J Miller; Arthur Christopoulos; Brian K Kobilka; Denise Wootten; Georgios Skiniotis; Patrick M Sexton
Journal:  Nature       Date:  2017-04-24       Impact factor: 49.962

10.  Structure of the full-length glucagon class B G-protein-coupled receptor.

Authors:  Haonan Zhang; Anna Qiao; Dehua Yang; Linlin Yang; Antao Dai; Chris de Graaf; Steffen Reedtz-Runge; Venkatasubramanian Dharmarajan; Hui Zhang; Gye Won Han; Thomas D Grant; Raymond G Sierra; Uwe Weierstall; Garrett Nelson; Wei Liu; Yanhong Wu; Limin Ma; Xiaoqing Cai; Guangyao Lin; Xiaoai Wu; Zhi Geng; Yuhui Dong; Gaojie Song; Patrick R Griffin; Jesper Lau; Vadim Cherezov; Huaiyu Yang; Michael A Hanson; Raymond C Stevens; Qiang Zhao; Hualiang Jiang; Ming-Wei Wang; Beili Wu
Journal:  Nature       Date:  2017-05-17       Impact factor: 49.962
  10 in total
  3 in total

Review 1.  Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors.

Authors:  Wijnand J C van der Velden; Laura H Heitman; Mette M Rosenkilde
Journal:  ACS Pharmacol Transl Sci       Date:  2020-03-18

2.  N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of GLP-2 receptor selectivity towards more GLP-1 receptor interaction.

Authors:  Maria Buur Nordskov Gabe; Laerke Smidt Gasbjerg; Sarina Gadgaard; Peter Lindquist; Jens Juul Holst; Mette Marie Rosenkilde
Journal:  Br J Pharmacol       Date:  2022-06-08       Impact factor: 9.473

3.  GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.

Authors:  Wijnand J C van der Velden; Florent X Smit; Charlotte B Christiansen; Thor C Møller; Gertrud M Hjortø; Olav Larsen; Sine P Schiellerup; Hans Bräuner-Osborne; Jens J Holst; Bolette Hartmann; Thomas M Frimurer; Mette M Rosenkilde
Journal:  ACS Pharmacol Transl Sci       Date:  2021-01-19
  3 in total

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