Literature DB >> 28853087

Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease.

N A Kraskovskaya1, E O Kukanova2, N S Lin'kova3,4, E A Popugaeva1, V Kh Khavinson2,5.   

Abstract

In primary culture of mouse hippocampal neurons, peptide EDR (200 ng/ml) under conditions of amyloid synaptotoxicity (a model of Alzheimer's disease) increased the number of mushroom spines by 71% and returned this parameter to the normal level. Under the same conditions, tripeptide KED (200 ng/ml) increased the number of mushroom spines in hippocampal neurons by 20%. Tripeptide EDR can be recommended for further experimental study as a candidate neuroprotective agent for prevention and treatment of Alzheimer's disease.

Entities:  

Keywords:  Alzheimer’s disease; culture of hippocampal neurons; dendritic spines; tripeptides; β-amyloid

Mesh：

Substances：

Year:  2017        PMID： 28853087     DOI： 10.1007/s10517-017-3847-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

Review 1.  Peptide Regulation of Cell Differentiation.

Authors:  Vladimir Khavinson; Natalia Linkova; Anastasiia Diatlova; Svetlana Trofimova
Journal:  Stem Cell Rev Rep       Date:  2020-02       Impact factor: 5.739

Review 2.  Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease.

Authors:  Anastasiia Ilina; Vladimir Khavinson; Natalia Linkova; Mikhael Petukhov
Journal:  Int J Mol Sci       Date:  2022-04-12       Impact factor: 6.208

3.  Systematic search for structural motifs of peptide binding to double-stranded DNA.

Authors:  Nina Kolchina; Vladimir Khavinson; Natalia Linkova; Alexander Yakimov; Dmitry Baitin; Arina Afanasyeva; Michael Petukhov
Journal:  Nucleic Acids Res       Date:  2019-11-18       Impact factor: 16.971

Review 4.  EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.

Authors:  Vladimir Khavinson; Natalia Linkova; Ekaterina Kozhevnikova; Svetlana Trofimova
Journal:  Molecules       Date:  2020-12-31       Impact factor: 4.411

5.  Peptide Regulation of Gene Expression: A Systematic Review.

Authors:  Vladimir Khatskelevich Khavinson; Irina Grigor'evna Popovich; Natalia Sergeevna Linkova; Ekaterina Sergeevna Mironova; Anastasiia Romanovna Ilina
Journal:  Molecules       Date:  2021-11-22       Impact factor: 4.411

6.  Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.

Authors:  Francesco Avolio; Stefano Martinotti; Vladimir Kh Khavinson; Jessica Elisabetta Esposito; Giulia Giambuzzi; Antonio Marino; Ekaterina Mironova; Riccardo Pulcini; Iole Robuffo; Giuseppina Bologna; Pasquale Simeone; Paola Lanuti; Simone Guarnieri; Svetlana Trofimova; Antonio Domenico Procopio; Elena Toniato
Journal:  Int J Mol Sci       Date:  2022-03-25       Impact factor: 5.923

7.  Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease.

Authors:  Vladimir Khavinson; Anastasiia Ilina; Nina Kraskovskaya; Natalia Linkova; Nina Kolchina; Ekaterina Mironova; Alexander Erofeev; Michael Petukhov
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-27

Review 8.  Peptide KED: Molecular-Genetic Aspects of Neurogenesis Regulation in Alzheimer's Disease.

Authors:  V Kh Khavinson; N S Lin'kova; R S Umnov
Journal:  Bull Exp Biol Med       Date:  2021-06-26       Impact factor: 0.804
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.