| Literature DB >> 28852849 |
Clemens Weber1, Jan Fischer1, Lisa Redelfs1, Franziska Rademacher1, Jürgen Harder1, Stephan Weidinger1, Zhihong Wu1,2, Ulf Meyer-Hoffert3.
Abstract
Proteases and their inhibitors play an important role in epidermal homeostasis. Their imbalance contributes to severe skin diseases. SPINK7 is a member of the SPINK protease inhibitor family and has been described so far as a cancer-related gene in the esophagus. Herein, we describe for the first time its expression in healthy human skin. Moreover, SPINK7 is up-regulated in inflammatory skin diseases like psoriasis and eczema as demonstrated by immunohistochemistry, though real-time PCR analyses revealed no significant up-regulation. In cultured keratinocytes, SPINK7 mRNA expression was up-regulated by IL-17A together with IFNγ. Our observation points to a role of SPINK7 in skin homeostasis and its involvement in inflammatory skin diseases.Entities:
Keywords: Epidermis; Esophageal cancer-related gene; KLK; Kallikrein-related peptidase; LEKTI; Protease inhibitor; Psoriasis
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Year: 2017 PMID： 28852849 DOI： 10.1007/s00403-017-1773-9
Source DB: PubMed Journal: Arch Dermatol Res ISSN： 0340-3696 Impact factor: 3.017