Literature DB >> 28852178

Novel approaches for identification of anti-tumor drugs and new bioactive compounds.

Manabu Kawada1,2, Sonoko Atsumi1, Shun-Ichi Wada1, Shuichi Sakamoto2.   

Abstract

Thanks to the pioneering work done by Professor Hamao Umezawa, bioactive compounds have been used in treatment of several diseases including cancer. In this review, we discuss our work, which focuses on developing new candidates for anti-tumor drugs by screening for bioactive natural compounds in microbial cultures using unique experimental systems. We summarize our recent progress including the following: (1) small-molecule modulators of tumor-stromal cell interactions, (2) inhibitors of three-dimensional spheroid formation of cancer cells, (3) multi-cancer cell panel screening and (4) new experimental animal models for cancer metastasis.The Journal of Antibiotics advance online publication, 30 August 2017; doi:10.1038/ja.2017.97.

Entities:  

Year:  2017        PMID： 28852178     DOI： 10.1038/ja.2017.97

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  30 in total

1.  Structure and biological properties of lentztrehalose: a novel trehalose analog.

Authors:  Shun-ichi Wada; Shun-ichi Ohba; Tetsuya Someno; Masaki Hatano; Akio Nomoto
Journal:  J Antibiot (Tokyo)       Date:  2014-01-22       Impact factor: 2.649

Review 2.  Anoikis molecular pathways and its role in cancer progression.

Authors:  Paolo Paoli; Elisa Giannoni; Paola Chiarugi
Journal:  Biochim Biophys Acta       Date:  2013-07-02

Review 3.  Targeting anoikis resistance in prostate cancer metastasis.

Authors:  Shinichi Sakamoto; Natasha Kyprianou
Journal:  Mol Aspects Med       Date:  2010-02-11

Review 4.  Trehalose: current use and future applications.

Authors:  Satoshi Ohtake; Y John Wang
Journal:  J Pharm Sci       Date:  2011-02-18       Impact factor: 3.534

5.  Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.

Authors:  Hikaru Abe; Manabu Kawada; Hiroyuki Inoue; Shun-ichi Ohba; Akio Nomoto; Takumi Watanabe; Masakatsu Shibasaki
Journal:  Org Lett       Date:  2013-04-17       Impact factor: 6.005

6.  Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095).

Authors:  P G Plagemann; M Behrens
Journal:  Cancer Res       Date:  1976-10       Impact factor: 12.701

7.  Phthoxazolin A inhibits prostate cancer growth by modulating tumor-stromal cell interactions.

Authors:  Manabu Kawada; Hiroyuki Inoue; Ihomi Usami; Daishiro Ikeda
Journal:  Cancer Sci       Date:  2008-10-20       Impact factor: 6.716

8.  Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2.

Authors:  Manabu Kawada; Hiroyuki Inoue; Shun-Ichi Ohba; Masaki Hatano; Masahide Amemiya; Chigusa Hayashi; Ihomi Usami; Hikaru Abe; Takumi Watanabe; Naoko Kinoshita; Masayuki Igarashi; Tohru Masuda; Daishiro Ikeda; Akio Nomoto
Journal:  J Antibiot (Tokyo)       Date:  2013-05-01       Impact factor: 2.649

9.  Novel autophagy inducers lentztrehaloses A, B and C.

Authors:  Shun-ichi Wada; Yumiko Kubota; Ryuichi Sawa; Maya Umekita; Masaki Hatano; Shun-ichi Ohba; Chigusa Hayashi; Masayuki Igarashi; Akio Nomoto
Journal:  J Antibiot (Tokyo)       Date:  2015-03-11       Impact factor: 2.649

10.  A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors.

Authors:  H Yamazaki; Y Ohba; N Tamaoki; M Shibuya
Journal:  Jpn J Cancer Res       Date:  1990-08
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  4 in total

1.  Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.

Authors:  Yool Lee; Shi Yi Fong; Joy Shon; Shirley L Zhang; Rebekah Brooks; Nicholas F Lahens; Dechun Chen; Chi Van Dang; Jeffrey M Field; Amita Sehgal
Journal:  Sci Adv       Date:  2021-02-12       Impact factor: 14.136

Review 2.  Polyphenols as Promising Drugs against Main Breast Cancer Signatures.

Authors:  María Losada-Echeberría; María Herranz-López; Vicente Micol; Enrique Barrajón-Catalán
Journal:  Antioxidants (Basel)       Date:  2017-11-07

3.  Laminarin from Seaweed (Laminaria japonica) Inhibits Hepatocellular Carcinoma Through Upregulating Senescence Marker Protein-30.

Authors:  Lin Tian; Chun-Mei Li; Yan-Fei Li; Tian-Ming Huang; Nai-Xia Chao; Guo-Rong Luo; Fa-Rong Mo
Journal:  Cancer Biother Radiopharm       Date:  2020-03-10       Impact factor: 3.099

Review 4.  Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy.

Authors:  Itika Arora; Manvi Sharma; Trygve O Tollefsbol
Journal:  Int J Mol Sci       Date:  2019-09-14       Impact factor: 5.923
  4 in total

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