OBJECTIVE: Obesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obese children and adolescents from Salvador, Brazil. METHOD: A fasting venous blood sample was obtained from 90 consecutive obese individuals aged 8-18 years, of both sexes, for laboratory determinations of glycated hemoglobin, basal insulin, and the Homeostasis Model Assessment Insulin Resistance index. The clinical evaluation included weight, height, waist circumference, assessment of pubertal development, and acanthosis nigricans research. The body mass index/age indicator was used for the severity of overweight assessment. RESULTS: Glycemic alterations were evidenced clinically and biochemically, although these individuals had no complaints or symptoms related to blood sugar levels. Quantitative and qualitative variables were respectively expressed measures of central tendency/dispersion and simple/relative frequency, using the SPSS, version 20.0. A p-value <0.05 was considered significant. CONCLUSION: Notably, this study found a high prevalence of glucose and insulin disorders in asymptomatic obese children and adolescents.
OBJECTIVE: Obesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obesechildren and adolescents from Salvador, Brazil. METHOD: A fasting venous blood sample was obtained from 90 consecutive obese individuals aged 8-18 years, of both sexes, for laboratory determinations of glycated hemoglobin, basal insulin, and the Homeostasis Model Assessment Insulin Resistance index. The clinical evaluation included weight, height, waist circumference, assessment of pubertal development, and acanthosis nigricans research. The body mass index/age indicator was used for the severity of overweight assessment. RESULTS: Glycemic alterations were evidenced clinically and biochemically, although these individuals had no complaints or symptoms related to blood sugar levels. Quantitative and qualitative variables were respectively expressed measures of central tendency/dispersion and simple/relative frequency, using the SPSS, version 20.0. A p-value <0.05 was considered significant. CONCLUSION: Notably, this study found a high prevalence of glucose and insulin disorders in asymptomatic obesechildren and adolescents.
Authors: Jinling Wang; Hu Lin; Valentina Chiavaroli; Binghan Jin; Jinna Yuan; Ke Huang; Wei Wu; Guanping Dong; José G B Derraik; Junfen Fu Journal: Front Endocrinol (Lausanne) Date: 2022-05-19 Impact factor: 6.055
Authors: Ahmad Kamil Nur Zati Iwani; Muhammad Yazid Jalaludin; Abqariyah Yahya; Fazliana Mansor; Fuziah Md Zain; Janet Yeow Hua Hong; Ruziana Mona Wan Mohd Zin; Abdul Halim Mokhtar Journal: Front Endocrinol (Lausanne) Date: 2022-03-10 Impact factor: 5.555
Authors: Valter Paulo Neves Miranda; Paulo Roberto Dos Santos Amorim; Ronaldo Rocha Bastos; Karina Lúcia Ribeiro Canabrava; Márcio Vidigal Miranda Júnior; Fernanda Rocha Faria; Sylvia do Carmo Castro Franceschini; Maria do Carmo Gouveia Peluzio; Silvia Eloiza Priore Journal: Mediators Inflamm Date: 2020-07-09 Impact factor: 4.711