Literature DB >> 2884992

Investigation of the role of Ca2+ and calmodulin in the regulation of platelet guanylate cyclase activity.

S Mac Neil.   

Abstract

Both soluble and particulate forms of human platelet guanylate cyclase were found to be sensitive to sub-micromolar concentrations of free Ca2+; soluble enzyme activity increased as Ca2+ was increased from 10 nM to 1 microM; particulate enzyme activity showed a biphasic response to Ca2+, with maximal enzyme activity between 1 and 10 nM free Ca2+ and inhibition occurring at higher Ca2+ concentrations. Neither Ca2+-sensitivity appeared to be calmodulin-dependent.

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Year:  1987        PMID： 2884992      PMCID： PMC1147748          DOI： 10.1042/bj2420607

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

Review 1.  Cyclic GMP metabolism and involvement in biological regulation.

Authors:  N D Goldberg; M K Haddox
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  GTP not cyclic GMP enhances secretion from permeabilized platelets.

Authors:  R J Haslam; M M Davidson
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

4.  Factors affecting the activity of guanylate cyclase in lysates of human blood platelets.

Authors:  A F Adams; R J Haslam
Journal:  Biochem J       Date:  1978-07-15       Impact factor: 3.857

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Effects of extracellular calmodulin and calmodulin antagonists on B16 melanoma cell growth.

Authors:  S Mac Neil; S W Walker; H J Senior; S S Bleehen; S Tomlinson
Journal:  J Invest Dermatol       Date:  1984-07       Impact factor: 8.551

7.  Activation by a calcium-binding protein of guanylate cyclase in Tetrahymena pyriformis.

Authors:  S Nagao; Y Suzuki; Y Watanabe; Y Nozawa
Journal:  Biochem Biophys Res Commun       Date:  1979-09-12       Impact factor: 3.575

8.  Lack of tissue specificity of calmodulin: a rapid and high-yield purification method.

Authors:  S Kakiuchi; K Sobue; R Yamazaki; J Kambayashi; M Sakon; G Kosaki
Journal:  FEBS Lett       Date:  1981-04-20       Impact factor: 4.124

9.  Biphasic Ca2+ response of adenylate cyclase. The role of calmodulin in its activation by Ca2+ ions.

Authors:  T J Resink; S Stucki; G Y Grigorian; A Zschauer; F R Bühler
Journal:  Eur J Biochem       Date:  1986-01-15

10.  Calmodulin activation of cyclic AMP phosphodiesterase in the B16 mouse melanoma.

Authors:  S W Walker; S Mac Neil; H J Senior; S S Bleehen; S Tomlinson
Journal:  Biochem J       Date:  1984-05-01       Impact factor: 3.857
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  2 in total

1.  Particulate guanylate cyclase and adenylate cyclase activities after activation with various agents in rabbit platelets. An ultracytochemical study.

Authors:  A Spreca; M G Rambotti; R Donato
Journal:  Histochem J       Date:  1991-03

2.  Atrial natriuretic peptide involvement in human platelet aggregability in vitro.

Authors:  R Pella; A von Ruecker; F Bidlingmaier
Journal:  Klin Wochenschr       Date:  1988-01-15
  2 in total

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