Nasim Zamani1,2, Hossein Hassanian-Moghaddam1,2, Maziar Shojaei3, Sara Rahimian4. 1. a Toxicological Research Center, Department of Clinical Toxicology , Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 2. b Ministry of Health , Excellence Centre of Clinical Toxicology , Tehran , Iran. 3. c Department of Neurology , Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran. 4. d Ophtalmology Clinic , Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
Abstract
PURPOSE: Following methanol intoxication, optic nerve neuropathy may occur, which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO in improvement of the visual disturbances in methanol-intoxicated patients. MATERIALS AND METHODS: In a case-control study, all patients who had referred to our toxicology centre with confirmed diagnosis of methanol toxicity were considered to be included. Of them, those who had referred with visual disturbances, survived, and their visual disturbances had not improved after haemodialysis were entered. Cases received EPO and corticosteroids while controls only received corticosteroids. They were then compared regarding their visual outcome. RESULTS: All five patients in the control group mentioned that after discharge, their visual acuity had improved while in the cases, three mentioned visual improvement, two mentioned their visual acuity had deteriorated after discharge, two mentioned no change in their visual acuity and three mentioned that their visual acuity had first improved but then deteriorated with a mean two-month interval period. In fundoscopic evaluations, two controls had normal fundospcopy while eight cases had abnormal fundoscopy (p = 0.055). CONCLUSIONS: Protective effect of EPO on methanol-induced optic nerve may be strong at the beginning of the intervention but is probably transient.
PURPOSE: Following methanol intoxication, optic nerve neuropathy may occur, which is currently treated by different therapeutic regimens. Erythropoietin (EPO) has recently been introduced as a good therapeutic option in methanol-induced optic neuropathy. The aim of the current study was to evaluate the efficacy of EPO in improvement of the visual disturbances in methanol-intoxicated patients. MATERIALS AND METHODS: In a case-control study, all patients who had referred to our toxicology centre with confirmed diagnosis of methanoltoxicity were considered to be included. Of them, those who had referred with visual disturbances, survived, and their visual disturbances had not improved after haemodialysis were entered. Cases received EPO and corticosteroids while controls only received corticosteroids. They were then compared regarding their visual outcome. RESULTS: All five patients in the control group mentioned that after discharge, their visual acuity had improved while in the cases, three mentioned visual improvement, two mentioned their visual acuity had deteriorated after discharge, two mentioned no change in their visual acuity and three mentioned that their visual acuity had first improved but then deteriorated with a mean two-month interval period. In fundoscopic evaluations, two controls had normal fundospcopy while eight cases had abnormal fundoscopy (p = 0.055). CONCLUSIONS: Protective effect of EPO on methanol-induced optic nerve may be strong at the beginning of the intervention but is probably transient.
Authors: Jacek Baj; Alicja Forma; Joanna Kobak; Magdalena Tyczyńska; Iga Dudek; Amr Maani; Grzegorz Teresiński; Grzegorz Buszewicz; Jacek Januszewski; Jolanta Flieger Journal: Int J Environ Res Public Health Date: 2022-03-06 Impact factor: 3.390