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Literature DB >> 28849572

Pharmacologic Manipulation of Wnt Signaling and Cancer Stem Cells.

Yann Duchartre¹, Yong-Mi Kim¹, Michael Kahn^2,3.

Abstract

Wnt (Wingless-related integration site)-signaling orchestrates self-renewal programs in normal somatic stem cells as well as in cancer stem cells. Aberrant Wnt signaling is associated with a wide variety of malignancies and diseases. Although our understanding has increased tremendously over the past decade, therapeutic targeting of the dysregulated Wnt pathway remains a challenge. Here we review recent preclinical and clinical therapeutic approaches to target the Wnt pathway.

Entities: CellLine Chemical Disease Gene Species

Keywords: Cancer stem cells; Clinical trial; Drug resistance; Self-renewal; Somatic stem cells; Wnt signaling

Mesh：

Substances：
Antineoplastic Agents

Year: 2017 PMID： 28849572 PMCID： PMC7473415 DOI： 10.1007/978-1-4939-7027-8_18

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

113 in total

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Journal: Inflamm Bowel Dis Date: 2010-05 Impact factor: 5.325

2. Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells.

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Journal: FEBS Lett Date: 2002-11-06 Impact factor: 4.124

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Journal: J Cell Biochem Date: 2012-01 Impact factor: 4.429

Review 4. Notch signaling in the regulation of stem cell self-renewal and differentiation.

Authors: Jianing Liu; Chihiro Sato; Massimiliano Cerletti; Amy Wagers
Journal: Curr Top Dev Biol Date: 2010 Impact factor: 4.897

5. Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.

Authors: Miki Shitashige; Yasuyoshi Naishiro; Masashi Idogawa; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Journal: Gastroenterology Date: 2007-01-05 Impact factor: 22.682

6. Chronic versus acute myelogenous leukemia: a question of self-renewal.

Authors: Catriona H M Jamieson; Irving L Weissman; Emmanuelle Passegué
Journal: Cancer Cell Date: 2004-12 Impact factor: 31.743

7. Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia stem cells in CML.

Authors: Florian H Heidel; Lars Bullinger; Zhaohui Feng; Zhu Wang; Tobias A Neff; Lauren Stein; Demetrios Kalaitzidis; Steven W Lane; Scott A Armstrong
Journal: Cell Stem Cell Date: 2012-04-06 Impact factor: 24.633

Review 8. WNT and beta-catenin signalling: diseases and therapies.

Authors: Randall T Moon; Aimee D Kohn; Giancarlo V De Ferrari; Ajamete Kaykas
Journal: Nat Rev Genet Date: 2004-09 Impact factor: 53.242

9. Activation of intracellular calcium by multiple Wnt ligands and translocation of β-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/β-catenin pathways.

Authors: Christopher Thrasivoulou; Michael Millar; Aamir Ahmed
Journal: J Biol Chem Date: 2013-10-24 Impact factor: 5.157