OBJECTIVE: We assessed the impact of treatment preferences in second-line chemotherapy on breast cancer prognosis using the SELECT BC study. METHODS: The SELECT BC study was performed in patients with HER2-negative metastatic breast cancer treated with initial chemotherapy. From these patients, 618 were assigned to 2 groups (S-1 group, 309; taxane group, 309). The S-1 and taxane groups were each subdivided into 3 groups: crossover group, protocol-recommended group, and other group, and the analysis of overall survival (OS) was performed using Cox regression with inverse probability weighting, to adjust for postrandomization confounding. RESULTS: In the taxane group, the OS of the crossover group (39.6 months) was better than that of the protocol-recommended group (35.7 months) and the other chemotherapy group (36.9 months) (vs. the protocol-recommended group, HR 0.72 [95% CI 0.52-0.98], p = 0.037; vs. the other chemotherapy group, HR 0.71 [95% CI 0.43-1.18], p = 0.183). In the S-1 group, there was no statistically significant difference in OS between the 3 groups. CONCLUSION: The study of the combination of first-line chemotherapy and second-line chemotherapy showed that S-1 might be recommended as a second-line chemotherapy in patients in whom taxane was the primary chemotherapy.
RCT Entities:
OBJECTIVE: We assessed the impact of treatment preferences in second-line chemotherapy on breast cancer prognosis using the SELECT BC study. METHODS: The SELECT BC study was performed in patients with HER2-negative metastatic breast cancer treated with initial chemotherapy. From these patients, 618 were assigned to 2 groups (S-1 group, 309; taxane group, 309). The S-1 and taxane groups were each subdivided into 3 groups: crossover group, protocol-recommended group, and other group, and the analysis of overall survival (OS) was performed using Cox regression with inverse probability weighting, to adjust for postrandomization confounding. RESULTS: In the taxane group, the OS of the crossover group (39.6 months) was better than that of the protocol-recommended group (35.7 months) and the other chemotherapy group (36.9 months) (vs. the protocol-recommended group, HR 0.72 [95% CI 0.52-0.98], p = 0.037; vs. the other chemotherapy group, HR 0.71 [95% CI 0.43-1.18], p = 0.183). In the S-1 group, there was no statistically significant difference in OS between the 3 groups. CONCLUSION: The study of the combination of first-line chemotherapy and second-line chemotherapy showed that S-1 might be recommended as a second-line chemotherapy in patients in whom taxane was the primary chemotherapy.
Authors: J Sjöström; C Blomqvist; H Mouridsen; A Pluzanska; S Ottosson-Lönn; N O Bengtsson; B Ostenstad; I Mjaaland; M Palm-Sjövall; E Wist; V Valvere; H Anderson; J Bergh Journal: Eur J Cancer Date: 1999-08 Impact factor: 9.162
Authors: Frank Loganzo; Carolyn M Discafani; Tami Annable; Carl Beyer; Sylvia Musto; Malathi Hari; Xingzhi Tan; Carolyn Hardy; Richard Hernandez; Michelle Baxter; Thiruvikraman Singanallore; Gulnaz Khafizova; Marianne S Poruchynsky; Tito Fojo; James A Nieman; Semiramis Ayral-Kaloustian; Arie Zask; Raymond J Andersen; Lee M Greenberger Journal: Cancer Res Date: 2003-04-15 Impact factor: 12.701
Authors: L Gianni; E Munzone; G Capri; F Villani; C Spreafico; E Tarenzi; F Fulfaro; A Caraceni; C Martini; A Laffranchi Journal: J Natl Cancer Inst Date: 1995-08-02 Impact factor: 13.506