Renal function after off-pump versus on-pump coronary artery bypass grafting.

Background Renal dysfunction is a well-recognized major complication after coronary artery bypass grafting. Off-pump coronary artery bypass theoretically appears to have less impact on renal function. We estimated preoperative and postoperative creatinine clearance as a marker of renal dysfunction in patients undergoing off-pump and on-pump coronary artery bypass. Methods Thirty patients undergoing coronary artery bypass were randomly allocated to undergo either on-pump ( n = 15) or off-pump surgery ( n = 15). The two groups had similar preoperative demographic characteristics. Serum creatinine and creatinine clearance were measured for 4 days postoperatively and the results were compared with preoperative levels. Results The rise in serum creatinine on postoperative day 1 was 0.28 mgċdL-1 in the on-pump group and 0.22 mgċdL-1 in the off-pump group ( p = 0.27); on postoperative day 4 it was 0.15 mgċdL-1 and 0.10 mgċdL-1, respectively, ( p = 0.28). Similarly, the fall in creatinine clearance was 17.34 mLċmin-1 in the on-pump group and 19.62 mLċmin-1 in the off-pump group on postoperative day 1 ( p = 0.42), and 10.9 and 10.94 mLċmin-1, respectively, on postoperative day 4 ( p = 0.64). Conclusion Renal function is not affected by the technique of coronary artery bypass surgery, whether with or without cardiopulmonary bypass, in spite of the theoretical advantage of off-pump surgery. Our study suggests that off-pump coronary artery bypass surgery does not confer significant protection from postoperative renal dysfunction in low-risk patients, when compared with on-pump surgery.

RCT Entities:   Population Interventions Outcomes