Zerwa Farooq1, Ashkan Heshmatzadeh Behzadi1, Jon D Blumenfeld2, Yize Zhao3, Martin R Prince4. 1. Department of Radiology, Weill Cornell Medical Center, New York, NY, United States. 2. The Rogosin Institute, United States; Division of Nephrology, Hypertenson, and Transplant Medicine, Department of Medicine, Weill Cornell Medical Center, United States. 3. Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, NY 10021, United States. 4. Department of Radiology, Weill Cornell Medical Center, New York, NY, United States; Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States. Electronic address: map2008@med.cornell.edu.
Abstract
PURPOSE: To compare MRI segmentation methods for measuring liver cyst volumes in autosomal dominant polycystic kidney disease (ADPKD). METHODS: Liver cyst volumes in 42 ADPKD patients were measured using region growing, thresholding and cyst diameter techniques. Manual segmentation was the reference standard. RESULTS: Root mean square deviation was 113, 155, and 500 for cyst diameter, thresholding and region growing respectively. Thresholding error for cyst volumes below 500ml was 550% vs 17% for cyst volumes above 500ml (p<0.001). CONCLUSION: For measuring volume of a small number of cysts, cyst diameter and manual segmentation methods are recommended. For severe disease with numerous, large hepatic cysts, thresholding is an acceptable alternative.
PURPOSE: To compare MRI segmentation methods for measuring liver cyst volumes in autosomal dominant polycystic kidney disease (ADPKD). METHODS: Liver cyst volumes in 42 ADPKDpatients were measured using region growing, thresholding and cyst diameter techniques. Manual segmentation was the reference standard. RESULTS: Root mean square deviation was 113, 155, and 500 for cyst diameter, thresholding and region growing respectively. Thresholding error for cyst volumes below 500ml was 550% vs 17% for cyst volumes above 500ml (p<0.001). CONCLUSION: For measuring volume of a small number of cysts, cyst diameter and manual segmentation methods are recommended. For severe disease with numerous, large hepatic cysts, thresholding is an acceptable alternative.
Authors: Xiaorui Yin; Jon D Blumenfeld; Sadjad Riyahi; Xianfu Luo; Hanna Rennert; Irina Barash; Martin R Prince Journal: Kidney Int Rep Date: 2020-11-01