G Shalom1,2, E Magen2,3, M Babaev2, S Tiosano4, D A Vardy1,2, D Linder5,6, A Horev1,2, A Saadia1,2, D Comaneshter7, N Agmon-Levin8,9, A D Cohen6,10. 1. Department of Dermatology and Venereology, Soroka Medical Center, Beer-Sheva, Israel. 2. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. 3. Leumit Health Services, Barzilai Medical Center, Medical Director of South Region, Ashkelon, Israel. 4. Department of Medicine 'B', Sheba medical center and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. 5. Section of Biostatistics, University of Oslo, Oslo, Norway. 6. Medical University of Graz, Graz, Austria. 7. Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel. 8. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. 9. The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv, Israel. 10. Division of Community Health, Faculty of Health Sciences, Siaal Research Center for Family Medicine and Primary Care, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Abstract
BACKGROUND: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process. OBJECTIVE: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. METHODS: A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. RESULTS: The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1-1.2, P < 0.001) and its components - obesity (OR = 1.2, 95% CI 1.1-1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01-1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1-1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1-1.2, P < 0.001). CONCLUSIONS: CU patients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
BACKGROUND: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process. OBJECTIVE: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. METHODS: A cross-sectional study of CUpatients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of 6 weeks) from 2002 to 2012. Data regarding the prevalence of metabolic syndrome, its components and possible complications were collected. RESULTS: The study included 11 261 patients with CU and 67 216 controls. In a univariate analysis, CU was significantly associated with higher body mass index (BMI) and a higher prevalence of obesity, diabetes, hyperlipidaemia, hypertension, metabolic syndrome, chronic renal failure and gout. Multivariate analysis demonstrated a significant association between CU and metabolic syndrome (OR = 1.12, 95% CI 1.1-1.2, P < 0.001) and its components - obesity (OR = 1.2, 95% CI 1.1-1.3, P < 0.001), diabetes (OR = 1.08, 95% CI 1.01-1.15, P = 0.001), hyperlipidaemia (OR = 1.2, 95% CI 1.1-1.2, P < 0.001) and hypertension (OR = 1.1, 95% CI 1.1-1.2, P < 0.001). CONCLUSIONS:CUpatients may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
Authors: Fu-Shun Yen; Chih-Cheng Hsu; Kai-Chieh Hu; Yu-Tung Hung; Chung Y Hsu; James Cheng-Chung Wei; Chii-Min Hwu Journal: Int J Environ Res Public Health Date: 2022-09-03 Impact factor: 4.614