Literature DB >> 28844895

The suitability of common compressibility equations for characterizing plasticity of diverse powders.

Shubhajit Paul1, Changquan Calvin Sun2.   

Abstract

The analysis of powder compressibility data yields useful information for characterizing compaction behavior and mechanical properties of powders, especially plasticity. Among the many compressibility equations proposed in powder compaction research, the Heckel equation and the Kawakita equation are the most commonly used, despite their known limitations. Systematic evaluation of the performance in analyzing compressibility data suggested the Kuentz-Leuenberger equation is superior to both the Heckel equation and the Kawakita equation for characterizing plasticity of powders exhibiting a wide range of mechanical properties.
Copyright © 2017 Elsevier B.V. All rights reserved.

Keywords:  Compressibility; Hardness; Heckel equation; Kawakita equation; Kuentz-Leuenberger equation; Plasticity; Tableting

Mesh:

Substances:

Year:  2017        PMID: 28844895     DOI: 10.1016/j.ijpharm.2017.08.096

Source DB:  PubMed          Journal:  Int J Pharm        ISSN: 0378-5173            Impact factor:   5.875


  5 in total

1.  Dependence of Friability on Tablet Mechanical Properties and a Predictive Approach for Binary Mixtures.

Authors:  Shubhajit Paul; Changquan Calvin Sun
Journal:  Pharm Res       Date:  2017-10-05       Impact factor: 4.200

2.  Modulating Sticking Propensity of Pharmaceuticals Through Excipient Selection in a Direct Compression Tablet Formulation.

Authors:  Shubhajit Paul; Changquan Calvin Sun
Journal:  Pharm Res       Date:  2018-03-30       Impact factor: 4.200

3.  Reduced Fine API Agglomeration After Dry Coating for Enhanced Blend Uniformity and Processability of Low Drug Loaded Blends.

Authors:  Sangah S Kim; Chelsea Castillo; Muhammad Sayedahmed; Rajesh N Davé
Journal:  Pharm Res       Date:  2022-07-26       Impact factor: 4.580

4.  Compression Modulus and Apparent Density of Polymeric Excipients during Compression-Impact on Tabletability.

Authors:  Barbara V Schönfeld; Ulrich Westedt; Karl G Wagner
Journal:  Pharmaceutics       Date:  2022-04-22       Impact factor: 6.525

5.  Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression.

Authors:  Qiuhua Luo; Qianying Zhang; Puxiu Wang
Journal:  Pharmaceutics       Date:  2022-08-21       Impact factor: 6.525

  5 in total

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