| Literature DB >> 28844895 |
Shubhajit Paul1, Changquan Calvin Sun2.
Abstract
The analysis of powder compressibility data yields useful information for characterizing compaction behavior and mechanical properties of powders, especially plasticity. Among the many compressibility equations proposed in powder compaction research, the Heckel equation and the Kawakita equation are the most commonly used, despite their known limitations. Systematic evaluation of the performance in analyzing compressibility data suggested the Kuentz-Leuenberger equation is superior to both the Heckel equation and the Kawakita equation for characterizing plasticity of powders exhibiting a wide range of mechanical properties.Keywords: Compressibility; Hardness; Heckel equation; Kawakita equation; Kuentz-Leuenberger equation; Plasticity; Tableting
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Year: 2017 PMID: 28844895 DOI: 10.1016/j.ijpharm.2017.08.096
Source DB: PubMed Journal: Int J Pharm ISSN: 0378-5173 Impact factor: 5.875