Literature DB >> 28844332

The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production.

Alexander G Allen1, Scott Morgans1, Eric Smith1, Mariah M Aron1, James K Jancovich2.   

Abstract

The iridovirus RNase III gene is one of 26 conserved core genes among the family Iridoviridae. Initial studies suggest this viral protein functions to suppress RNA interference pathways that may attack viral RNA during infection. Therefore, to determine if the Ambystoma tigrinum virus (ATV) RNase III-like gene (ORF 25R) can modulate the host innate immune response fish and human cells ectopically expressing 25R were treated with polyI:C and monitored for interferon synthesis and phosphorylation of eIF2α and PKR. We found a decrease in cellular IFN production and modulation of the PKR pathway. In addition, ATV deleted of the RNase III gene (ATVΔ25R) shows reduced pathogenicity in tiger salamanders. Collectively our data suggest that the ATV 25R protein is a pathogenesis factor that may function to help evade the host's immune response by masking activators of the IFN pathway.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Amphibian disease; Innate immunity; Interferon; PKR, eIF2α

Mesh：

Substances：

Year:  2017        PMID： 28844332      PMCID： PMC5623656          DOI： 10.1016/j.virol.2017.08.013

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  35 in total

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Authors:  Jeffrey O Langland; Jason M Cameron; Michael C Heck; James K Jancovich; Bertram L Jacobs
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Authors:  Mazhar Hussain; Alexander M Abraham; Sassan Asgari
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3.  Inducers of interferon and host resistance, V. In vitro studies.

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4.  Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.

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Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

5.  Viral class 1 RNase III involved in suppression of RNA silencing.

Authors:  Jan F Kreuze; Eugene I Savenkov; Wilmer Cuellar; Xiangdong Li; Jari P T Valkonen
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

6.  Transcriptome analysis of Frog virus 3, the type species of the genus Ranavirus, family Iridoviridae.

Authors:  S Majji; V Thodima; R Sample; D Whitley; Y Deng; J Mao; V G Chinchar
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7.  Identification of essential and non-essential genes in Ambystoma tigrinum virus.

Authors:  Mariah M Aron; Alexander G Allen; Mathew Kromer; Hector Galvez; Brianna Vigil; James K Jancovich
Journal:  Virus Res       Date:  2016-03-26       Impact factor: 3.303

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Journal:  Nucleic Acids Res       Date:  2014-10-01       Impact factor: 16.971

Review 10.  Recombinant Ranaviruses for Studying Evolution of Host-Pathogen Interactions in Ectothermic Vertebrates.

Authors:  Jacques Robert; James K Jancovich
Journal:  Viruses       Date:  2016-07-06       Impact factor: 5.048
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Authors:  Trung P Huynh; James K Jancovich; Latha Tripuraneni; Michael C Heck; Jeffrey O Langland; Bertram L Jacobs
Journal:  Virology       Date:  2017-09-14       Impact factor: 3.616

2.  Antagonism of the Protein Kinase R Pathway in Human Cells by Rhesus Cytomegalovirus.

Authors:  Stephanie J Child; Sarah E Hickson; Avraham Bayer; Daniel Malouli; Klaus Früh; Adam P Geballe
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Review 3.  RNase III, Ribosome Biogenesis and Beyond.

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Journal:  Microorganisms       Date:  2021-12-17
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