J Coll1, S Videla2, A Leon3, A Ornelas4, F García3, E Fernández3, J L Blanco3, A Carrillo5, I Bravo4, M Meulbroek5, F García-Cuyas4, V González6, J Casabona6, L Leal3, B Clotet7, C Brander8. 1. AIDS Research Institute-IrsiCaixa Foundation, Spain; Lluita Contra La SIDA Foundation, University Hospital Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona (UAB), Spain. Electronic address: pcoll@irsicaixa.es. 2. Lluita Contra La SIDA Foundation, University Hospital Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona (UAB), Spain; Department of Experimental and Health Sciences, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Spain. 3. Hospital Clinic-Fundació Clinic-IDIBAPS, HIVACAT, Universitat de Barcelona, Spain. 4. Lluita Contra La SIDA Foundation, University Hospital Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona (UAB), Spain. 5. BCN Checkpoint, Spain. 6. Centre Estudis Epidemiologics sobre les Infeccions de Transmissio Sexual i Sida de Catalunya (CEEISCAT), Dept Salut, Generalitat de Catalunya, Catalunya/CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. 7. AIDS Research Institute-IrsiCaixa Foundation, Spain; Lluita Contra La SIDA Foundation, University Hospital Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona (UAB), Spain; Universitat de Vic-Universitat Central de Catalunya, Catalunya, Spain. 8. AIDS Research Institute-IrsiCaixa Foundation, Spain; Universitat de Vic-Universitat Central de Catalunya, Catalunya, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Abstract
OBJECTIVE: To provide data on incidence of early diagnosis of HIV infections and define prevalence and incidence of asymptomatic sexually transmitted infections (STI) in men who have sex with men (MSM). METHODS: We assessed a prospective cohort study of HIV-uninfected MSM at high risk for HIV infection. Participants were selected through a risk-assessment questionnaire, and they were screened for HIV infection (quarterly) and for other STI (yearly): syphilis, and hepatitis A, B and C (serology); Chlamydia trachomatis and Neisseria gonorrhoeae in penis and rectum; and human papillomavirus in anus and mouth (PCR). RESULTS: Between November 2009 and October 2012, a total of 258 HIV-uninfected MSM at high risk for HIV infection were included and followed up for a median of 2 years (interquartile range 1.4, 2.5). Nineteen acute HIV infections were diagnosed (incidence, 3.9 per 100 person-years). Prevalence of STI at baseline was follows: syphilis 8.4% (95% confidence interval (CI) 5.4-12.7); hepatitis C virus (HCV) 2.0% (95% CI 0.7-4.8); C. trachomatis in penis 3.2% (95% CI 1.5-6.5) and in rectum 6.5% (95% CI 3.9-10.5); N. gonorrhoeae in penis 2.0% (95% CI 0.8-5.0) and in rectum 6.1% (95% CI 3.6-10.1); human papillomavirus in anal canal 75.7% (95% CI 68.8-81.5) and in mouth 3.8% (95% CI 1.8-7.7). CONCLUSIONS: The implementation of the Check-Ear Project in a MSM community centre allowed for the identification of early HIV infections and asymptomatic STI among MSM. The high incidence of HIV infections and the high prevalence of STI strongly support the recommendation of periodic screenings among sexually active MSM.
OBJECTIVE: To provide data on incidence of early diagnosis of HIV infections and define prevalence and incidence of asymptomatic sexually transmitted infections (STI) in men who have sex with men (MSM). METHODS: We assessed a prospective cohort study of HIV-uninfected MSM at high risk for HIV infection. Participants were selected through a risk-assessment questionnaire, and they were screened for HIV infection (quarterly) and for other STI (yearly): syphilis, and hepatitis A, B and C (serology); Chlamydia trachomatis and Neisseria gonorrhoeae in penis and rectum; and human papillomavirus in anus and mouth (PCR). RESULTS: Between November 2009 and October 2012, a total of 258 HIV-uninfected MSM at high risk for HIV infection were included and followed up for a median of 2 years (interquartile range 1.4, 2.5). Nineteen acute HIV infections were diagnosed (incidence, 3.9 per 100 person-years). Prevalence of STI at baseline was follows: syphilis 8.4% (95% confidence interval (CI) 5.4-12.7); hepatitis C virus (HCV) 2.0% (95% CI 0.7-4.8); C. trachomatis in penis 3.2% (95% CI 1.5-6.5) and in rectum 6.5% (95% CI 3.9-10.5); N. gonorrhoeae in penis 2.0% (95% CI 0.8-5.0) and in rectum 6.1% (95% CI 3.6-10.1); human papillomavirus in anal canal 75.7% (95% CI 68.8-81.5) and in mouth 3.8% (95% CI 1.8-7.7). CONCLUSIONS: The implementation of the Check-Ear Project in a MSM community centre allowed for the identification of early HIV infections and asymptomatic STI among MSM. The high incidence of HIV infections and the high prevalence of STI strongly support the recommendation of periodic screenings among sexually active MSM.
Authors: Christoph D Spinner; Christoph Boesecke; Cornelius Jordan; Christoph Wyen; Tim Kümmerle; Gaby Knecht; Stefan Scholten; Alexander Zink; Ivanka Krznaric; Sebastian Noe Journal: Infection Date: 2018-02-19 Impact factor: 3.553
Authors: Nori Krabbenborg; Ralph Spijker; Anna Maria Żakowicz; Milo de Moraes; Titia Heijman; Eline Op de Coul Journal: AIDS Res Ther Date: 2021-06-23 Impact factor: 2.250