Literature DB >> 2884353

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay.

J Y Koh, D W Choi.   

Abstract

Measurement of lactate dehydrogenase (LDH) activity released to the extracellular bathing media has been found to be a simple yet quantitative method for assessing glutamate mediated central neuronal cell injury in cortical cell culture. Extracellular LDH is both chemically and biologically stable; the magnitude of LDH efflux in the cultures correlates in a linear fashion with the number of neurons damaged by glutamate exposure.

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Year:  1987        PMID： 2884353     DOI： 10.1016/0165-0270(87)90041-0

Source DB:  PubMed          Journal:  J Neurosci Methods        ISSN： 0165-0270            Impact factor:   2.390


  237 in total

1.  Glutaric aciduria type I: pathomechanisms of neurodegeneration.

Authors:  K Ullrich; B Flott-Rahmel; P Schluff; U Musshoff; A Das; T Lücke; R Steinfeld; E Christensen; C Jakobs; A Ludolph; A Neu; R Röper
Journal:  J Inherit Metab Dis       Date:  1999-06       Impact factor: 4.982

2.  The electrogenic sodium bicarbonate cotransporter: developmental expression in rat brain and possible role in acid vulnerability.

Authors:  R G Giffard; M C Papadopoulos; J A van Hooft; L Xu; R Giuffrida; H Monyer
Journal:  J Neurosci       Date:  2000-02-01       Impact factor: 6.167

3.  Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis.

Authors:  Johann S Braun; Jack E Sublett; Dorette Freyer; Tim J Mitchell; John L Cleveland; Elaine I Tuomanen; Joerg R Weber
Journal:  J Clin Invest       Date:  2002-01       Impact factor: 14.808

4.  EGCG ameliorates the suppression of long-term potentiation induced by ischemia at the Schaffer collateral-CA1 synapse in the rat.

Authors:  Jie Ding; Gang Fu; Yan Zhao; Zhenyong Cheng; Yang Chen; Bo Zhao; Wei He; Lian-Jun Guo
Journal:  Cell Mol Neurobiol       Date:  2011-11-11       Impact factor: 5.046

5.  Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin.

Authors:  Jing Chen-Roetling; Wenpei Liu; Raymond F Regan
Journal:  Free Radic Biol Med       Date:  2011-08-30       Impact factor: 7.376

6.  Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins.

Authors:  K M Abdel-Hamid; M Tymianski
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

7.  Involvement of illumination in indocyanine green toxicity after its washout in the ex vivo rat retina.

Authors:  Kazuhiro Tokuda; Charles F Zorumski; Yukitoshi Izumi
Journal:  Retina       Date:  2009-03       Impact factor: 4.256

8.  Oct-2 transcription factor binding activity and expression up-regulation in rat cerebral ischaemia is associated with a diminution of neuronal damage in vitro.

Authors:  Susanna Camós; Carme Gubern; Mónica Sobrado; Rocío Rodríguez; Víctor G Romera; María Ángeles Moro; Ignacio Lizasoain; Joaquín Serena; Judith Mallolas; Mar Castellanos
Journal:  Neuromolecular Med       Date:  2013-11-27       Impact factor: 3.843

9.  Effect of N-methyl-D-aspartate and potassium on striatal monoamine metabolism in immature rat: an in vivo microdialysis study.

Authors:  W Nakajima; A Ishida; M Ogasawara; G Takada
Journal:  Neurochem Res       Date:  1998-09       Impact factor: 3.996

10.  Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.

Authors:  D P Younkin; C M Tang; M Hardy; U R Reddy; Q Y Shi; S J Pleasure; V M Lee; D Pleasure
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205
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