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Literature DB >> 28843435

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission.

Elodie Bournique¹, Marina Dall'Osto¹, Jean-Sébastien Hoffmann¹, Valérie Bergoglio².

Abstract

Replication stress is a strong and early driving force for genomic instability and tumor development. Beside replicative DNA polymerases, an emerging group of specialized DNA polymerases is involved in the technical assistance of the replication machinery in order to prevent replicative stress and its deleterious consequences. During S-phase, altered progression of the replication fork by endogenous or exogenous impediments induces replicative stress, causing cells to reach mitosis with genomic regions not fully duplicated. Recently, specific mechanisms to resolve replication intermediates during mitosis with the aim of limiting DNA damage transmission to daughter cells have been identified. In this review, we detail the two major actions of specialized DNA polymerases that limit DNA damage transmission: the prevention of replicative stress by non-B DNA replication and the recovery of stalled replication forks.

Entities: Disease

Keywords: Common fragile sites; DNA damage transmission; Non-B DNA; Repetitive sequences; Replication stress; Specialized DNA polymerases

Mesh：

Substances：

Year: 2017 PMID： 28843435 DOI： 10.1016/j.mrfmmm.2017.08.002

Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433

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Cited

10 in total

1. A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1.

Authors: Marina Dall'Osto; Laura Pierini; Nicolas Valery; Jean-Sébastien Hoffmann; Marie-Jeanne Pillaire
Journal: Mol Cell Biol Date: 2021-08-16 Impact factor: 4.272

2. Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.

Authors: Wilfried M Guiblet; Marzia A Cremona; Robert S Harris; Di Chen; Kristin A Eckert; Francesca Chiaromonte; Yi-Fei Huang; Kateryna D Makova
Journal: Nucleic Acids Res Date: 2021-02-22 Impact factor: 16.971

3. Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.

Authors: Wei-Chung Tsao; Raquel Buj; Katherine M Aird; Julia M Sidorova; Kristin A Eckert
Journal: PLoS One Date: 2021-05-07 Impact factor: 3.240

Role of specialized DNA polymerases in the limitation of replicative stress and DNA damage transmission.

1. A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1.

2. Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.

3. Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.

4. A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance.

5. Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis.

Review 6. DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons.

7. Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes.

Review 8. Detours to Replication: Functions of Specialized DNA Polymerases during Oncogene-induced Replication Stress.

9. DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentation.

Review 10. When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis.